A New Sesquiterpene from the Fungus Penicillium sp. LPFH-hzw-zw1

Abstract

: An investigation of the secondary metabolites of the sea sediment-derived Penicillium sp. LPFH-ZW-1 resulted in the identification of a new compound, named penicipeneacid ( 1 ), along with seven known compounds. The structures of these compounds were established by extensive analysis of the 1D and 2D NMR data, combined with HRESIMS data. The absolute configuration of 1 was determined by comparing the experimental and predicted ECD spectra. The bicyclo[4.1.0]heptane nucleus in compounds 1 and 2 was rarely found in nature. The known compounds were identified to be sesquicaranoic acid B ( 2 ), 9-cycloneren-3,7,11-triol ( 3 ), fumiquinazoline J ( 4 ), versiquinazoline H ( 5 ), penipurdin A ( 6 ), questinol ( 7 ), and 2-hydroxy-4-ethoxybenzoic acid ( 8 ). Compounds 4 and 7 exhibited moderate cytotoxicity against MCF-7 and K562 tumor cell lines, with IC 50 values ranging from 12.6 to 37.1  M.