{"title":"A New Sesquiterpene from the Fungus Penicillium sp. LPFH-hzw-zw1","authors":"Wei Zhang, Qi Wang","doi":"10.25135/rnp.453.2402.3149","DOIUrl":null,"url":null,"abstract":": An investigation of the secondary metabolites of the sea sediment-derived Penicillium sp. LPFH-ZW-1 resulted in the identification of a new compound, named penicipeneacid ( 1 ), along with seven known compounds. The structures of these compounds were established by extensive analysis of the 1D and 2D NMR data, combined with HRESIMS data. The absolute configuration of 1 was determined by comparing the experimental and predicted ECD spectra. The bicyclo[4.1.0]heptane nucleus in compounds 1 and 2 was rarely found in nature. The known compounds were identified to be sesquicaranoic acid B ( 2 ), 9-cycloneren-3,7,11-triol ( 3 ), fumiquinazoline J ( 4 ), versiquinazoline H ( 5 ), penipurdin A ( 6 ), questinol ( 7 ), and 2-hydroxy-4-ethoxybenzoic acid ( 8 ). Compounds 4 and 7 exhibited moderate cytotoxicity against MCF-7 and K562 tumor cell lines, with IC 50 values ranging from 12.6 to 37.1 M.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":"150 5","pages":""},"PeriodicalIF":17.7000,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.25135/rnp.453.2402.3149","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
: An investigation of the secondary metabolites of the sea sediment-derived Penicillium sp. LPFH-ZW-1 resulted in the identification of a new compound, named penicipeneacid ( 1 ), along with seven known compounds. The structures of these compounds were established by extensive analysis of the 1D and 2D NMR data, combined with HRESIMS data. The absolute configuration of 1 was determined by comparing the experimental and predicted ECD spectra. The bicyclo[4.1.0]heptane nucleus in compounds 1 and 2 was rarely found in nature. The known compounds were identified to be sesquicaranoic acid B ( 2 ), 9-cycloneren-3,7,11-triol ( 3 ), fumiquinazoline J ( 4 ), versiquinazoline H ( 5 ), penipurdin A ( 6 ), questinol ( 7 ), and 2-hydroxy-4-ethoxybenzoic acid ( 8 ). Compounds 4 and 7 exhibited moderate cytotoxicity against MCF-7 and K562 tumor cell lines, with IC 50 values ranging from 12.6 to 37.1 M.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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