Novel pit and fissure sealant with nano-CaF2 and antibacterial monomer: Fluoride recharge, microleakage, sealing ability and cytotoxicity.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-04-05 DOI:10.4012/dmj.2023-166

Xiuzhi Fei, Yuncong Li, Qian Zhang, Chunli Tian, Yue Li, Qiannan Dong, M. Weir, Negar Homayounfar, Thomas W. Oates, Satoshi Imazato, Quan Dai, H. Xu, J. Ruan

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Abstract

Conventional resin-based sealants release minimal fluoride ions (F) and lack antibacterial activity. The objectives of this study were to: (1) develop a novel bioactive sealant containing calcium fluoride nanoparticles (nCaF2) and antibacterial dimethylaminohexadecyl methacrylate (DMAHDM), and (2) investigate mechanical performance, F recharge and re-release, microleakage, sealing ability and cytotoxicity. Helioseal F served as commercial control. The initial F release from sealant containing 20% nCaF2 was 25-fold that of Helioseal F. After ion exhaustion and recharge, the F re-release from bioactive sealant did not decrease with increasing number of recharge and re-release cycles. Elastic modulus of new bioactive sealant was 44% higher than Helioseal F. The new sealant had excellent sealing, minimal microleakage, and good cytocompatibility. Hence, the nanostructured sealant had substantial and sustained F release and antibacterial activity, good sealing ability and biocompatibility. The novel bioactive nCaF2 sealant is promising to provide long-term F ions for caries prevention.

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含有纳米 CaF2 和抗菌单体的新型坑隙封闭剂：氟补给、微渗漏、密封能力和细胞毒性。

传统的树脂密封剂只能释放极少量的氟离子（F），而且缺乏抗菌活性。本研究的目的是(1) 开发一种新型生物活性封闭剂，其中含有纳米氟化钙颗粒（nCaF2）和抗菌甲基丙烯酸二甲基氨基十六烷基酯（DMAHDM）；(2) 研究机械性能、氟离子补给和再释放、微渗漏、封闭能力和细胞毒性。Helioseal F 用作商业对照。含有 20% nCaF2 的密封剂的初始钙离子释放量是 Helioseal F 的 25 倍，在离子耗尽和再充电后，生物活性密封剂的钙离子再释放量并没有随着充电和再释放循环次数的增加而减少。新型生物活性密封剂的弹性模量比 Helioseal F 高 44%。新型密封剂具有出色的密封性、最小的微渗漏和良好的细胞相容性。因此，纳米结构密封剂具有大量和持续的 F 释放和抗菌活性、良好的密封能力和生物相容性。这种新型生物活性 nCaF2 密封剂有望为预防龋齿提供长期的 F 离子。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.