Effects of Orexin Receptor Antagonist on Cognitive Function in Adults: A Systematic Review

IF 0.3 Q4 PHARMACOLOGY & PHARMACY Current Drug Therapy Pub Date : 2024-04-04 DOI:10.2174/0115748855292051240327084430

Divya Jha, Aakriti Garg, M. A. Khan

{"title":"Effects of Orexin Receptor Antagonist on Cognitive Function in Adults: A\nSystematic Review","authors":"Divya Jha, Aakriti Garg, M. A. Khan","doi":"10.2174/0115748855292051240327084430","DOIUrl":null,"url":null,"abstract":"\n\nOrexin receptor antagonists (ORAs) are the emerging class of hypnotics\nused for the treatment of insomnia. However, from the available literature, the effect of ORA on\ncognitive functions is not clear yet. Therefore, the current study aimed to systematically evaluate the\neffect of ORA on cognitive function from available clinical studies.\n\n\n\nThe extensive literature search was conducted in various databases, including Pubmed,\nEmbase, Cochrane Library, and clinicaltrials.gov, using suitable keywords. The quality of the included\nstudies was evaluated using the Cochrane risk of bias tool (ROB2).\n\n\n\nWe obtained a total of 450 articles from different databases. Finally, 07 articles met the\ninclusion criteria and were included in the current systematic review for qualitative analysis. Available\nliterature showed conflicting results, with few studies showing no impact of ORA on cognitive\nfunction, while others reported dose-dependent adverse effects of ORA on cognitive function. The\nrisk of bias in included studies was found to be low.\n\n\n\nIn conclusion, ORA is generally safe in clinical doses. However, it is important to note\nthat there is a dose-dependent decline in cognitive function after the administration of ORA. Therefore,\nclinicians must be careful while prescribing ORA and adjust the dose as per the needs of the\nindividual patients and the potential risk factors.\n","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.3000,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Drug Therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0115748855292051240327084430","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}

引用次数: 0

Abstract

Orexin receptor antagonists (ORAs) are the emerging class of hypnotics used for the treatment of insomnia. However, from the available literature, the effect of ORA on cognitive functions is not clear yet. Therefore, the current study aimed to systematically evaluate the effect of ORA on cognitive function from available clinical studies. The extensive literature search was conducted in various databases, including Pubmed, Embase, Cochrane Library, and clinicaltrials.gov, using suitable keywords. The quality of the included studies was evaluated using the Cochrane risk of bias tool (ROB2). We obtained a total of 450 articles from different databases. Finally, 07 articles met the inclusion criteria and were included in the current systematic review for qualitative analysis. Available literature showed conflicting results, with few studies showing no impact of ORA on cognitive function, while others reported dose-dependent adverse effects of ORA on cognitive function. The risk of bias in included studies was found to be low. In conclusion, ORA is generally safe in clinical doses. However, it is important to note that there is a dose-dependent decline in cognitive function after the administration of ORA. Therefore, clinicians must be careful while prescribing ORA and adjust the dose as per the needs of the individual patients and the potential risk factors.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

奥列克辛受体拮抗剂对成人认知功能的影响系统综述

苏醒素受体拮抗剂（ORA）是一类新兴的用于治疗失眠的催眠药。然而，从现有文献来看，ORA对认知功能的影响尚不明确。因此，本研究旨在从现有的临床研究中系统评估 ORA 对认知功能的影响。我们使用合适的关键词在 Pubmed、Embase、Cochrane Library 和 clinicaltrials.gov 等多个数据库中进行了广泛的文献检索。我们从不同的数据库中共获得 450 篇文章。最后，有 07 篇文章符合纳入标准，被纳入本次系统综述进行定性分析。现有文献显示了相互矛盾的结果，少数研究显示 ORA 对认知功能没有影响，而其他研究则报告了 ORA 对认知功能的剂量依赖性不良影响。总之，ORA 的临床剂量一般是安全的。然而，需要注意的是，服用 ORA 后认知功能的下降与剂量有关。因此，临床医生在开具 ORA 处方时必须谨慎，并根据患者的个体需求和潜在的风险因素调整剂量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Current Drug Therapy PHARMACOLOGY & PHARMACY-

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Current Drug Therapy publishes frontier reviews of high quality on all the latest advances in drug therapy covering: new and existing drugs, therapies and medical devices. The journal is essential reading for all researchers and clinicians involved in drug therapy.