Sinonasal diffuse large B-cell lymphoma: own clinical observation and literature review

M. A. Mingalimov, E. Baryakh, O. Kochneva, E. Misyurina, Y. Y. Polyakov, E. Zhelnova, K. Yatskov, A. B. Makeshova, T. Tolstykh, T. S. Chudnova, D. D. Ivanova, D. V. Lebedev, E. Zotina, D. Gagloeva, M. Beregov, E. A. Mamatturdiev, I. Samsonova, M. A. Lysenko
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Abstract

Diffuse large B-cell lymphoma is the most common immunomorphological variant of lymphoma in adults. Extranodal lesions are observed in a third of patients at the disease onset. The organs most often involved are the gastrointestinal tract, testicles, bones, thyroid gland, and skin. Primary involvement of the nasal cavity and paranasal sinuses occur extremely rarely and cause diagnostic and therapeutic difficulties.The article demonstrates a rare clinical case of newly diagnosed diffuse large B-cell lymphoma with sinonasal tract involvement. It took 6 months to verify the final diagnosis. At the moment, the induction stage of treatment for diffuse large B-cell lymphoma continues, the achieved complete metabolic response is maintained.
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鼻窦弥漫性大 B 细胞淋巴瘤:临床观察和文献综述
弥漫大B细胞淋巴瘤是成人淋巴瘤中最常见的免疫形态学变异。三分之一的患者在发病时会出现结节外病变。最常受累的器官是胃肠道、睾丸、骨骼、甲状腺和皮肤。鼻腔和鼻窦原发受累的情况极为罕见,给诊断和治疗带来困难。本文展示了一例新诊断的弥漫大B细胞淋巴瘤鼻窦受累的罕见临床病例。该病例历时 6 个月才最终确诊。目前,弥漫大B细胞淋巴瘤的诱导治疗阶段仍在继续,已取得的完全代谢反应得以维持。
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