Dental and ENT Evaluation Before Liver Transplantation

IF 3.3 Q2 GASTROENTEROLOGY & HEPATOLOGY Journal of Clinical and Experimental Hepatology Pub Date : 2024-04-18 DOI:10.1016/j.jceh.2024.101431
Rakesh K. Jagdish , Preetam Chappity , S. Lata
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Abstract

The assessment of dental and ear, nose and throat (ENT) conditions holds significant importance in the pre-transplantation evaluation for individuals undergoing liver transplantation. This evaluation aims to address concerns related to dental and ENT issues both before and after liver transplantation. These concerns include the risk of sepsis, the impact of post-transplantation immunosuppression, the detection of existing malignancies, including oral potentially malignant disorders (OPMDs), and identifying any contraindications to the transplantation procedure. However, it is worth noting that there exists a notable absence of clear guidelines and protocols in the existing literature regarding this practice. Moreover, recent studies have presented conflicting results, and concerns have arisen regarding the cost-effectiveness of these evaluations. It is crucial to perform these investigations judiciously to avoid unnecessary testing burdens and delays in placing patients on waiting lists, particularly when considering live donor liver transplantation (LDLT) evaluations. A comprehensive examination of the oral and ENT regions, in conjunction with relevant laboratory tests, can play a pivotal role in identifying and managing oral and ENT diseases before the liver transplantation procedure. Timely recognition and treatment of potential issues are essential for minimizing perioperative morbidity and mortality. There is an evident need for prospective trials and studies to further explore and establish guidelines in the critical area of dental and ENT evaluation in liver transplantation recipients. Such research efforts would contribute significantly to enhancing our understanding and management of oral and ENT conditions in the pre-transplantation setting, ultimately improving patient care and outcomes.

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"肝移植前的牙科和内科评估"
在对接受肝脏移植的患者进行移植前评估时,牙科和耳鼻喉科(ENT)状况的评估非常重要。该评估旨在解决肝脏移植前后与牙科和耳鼻喉科相关的问题。这些问题包括败血症的风险、移植后免疫抑制的影响、现有恶性肿瘤(包括口腔潜在恶性疾病)的检测,以及确定移植手术的禁忌症。然而,值得注意的是,现有文献中明显缺乏有关这一做法的明确指南和协议。此外,近期的研究结果相互矛盾,人们对这些评估的成本效益也产生了担忧。明智地进行这些检查以避免不必要的检查负担和延误将患者列入候诊名单至关重要,尤其是在考虑进行活体肝移植(LDLT)评估时。对口腔和耳鼻喉区域进行全面检查,并结合相关实验室检测,可在肝脏移植手术前发现和控制口腔和耳鼻喉疾病方面发挥关键作用。及时发现和治疗潜在的问题对于最大限度地降低围手术期的发病率和死亡率至关重要。在肝移植受者的口腔和耳鼻喉科评估这一关键领域,显然需要进行前瞻性试验和研究,以进一步探索和制定指导方针。这些研究工作将极大地促进我们对移植前口腔和耳鼻喉科疾病的理解和管理,最终改善患者护理和治疗效果。
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来源期刊
Journal of Clinical and Experimental Hepatology
Journal of Clinical and Experimental Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
4.90
自引率
16.70%
发文量
537
审稿时长
64 days
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