Relationship between high sensitivity troponin I and clinical outcomes in non–acute coronary syndrome (non-ACS) acute heart failure patients – a one-year follow-up study

IF 1.4 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Indian heart journal Pub Date : 2024-03-01 DOI:10.1016/j.ihj.2024.04.003

Dr Abhishek Kumar , Dr Kader Muneer , Dr Naeem Qureshi

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Abstract

Objective

The primary objective of the study was to investigate the correlation between high-sensitivity troponin I (hsTropI) levels during hospitalization and the prognostic outcome in patients with non-acute coronary syndrome (non-ACS) acute heart failure, over a follow-up period of one year. The secondary objective was to assess and characterize acute heart failure during index hospitalization.

Methods

High sensitivity troponin I value was noted both at the time of admission and discharge. The correlation of admission hsTropI along with other parameters and risk factors with in-hospital mortality was studied. Patients of index hospitalization after discharge were followed up for one year and the composite endpoint of cardiovascular death or re-hospitalization for heart failure was noted. The correlation between admission and discharge hsTropI values with the composite endpoint was then analyzed.

Results

Out of 350 patients, 38 (10.8 %) patients died during index hospitalization while 142 patients (46 %) developed composite outcomes during follow-up. Age, previous history of heart failure, atrial fibrillation, low left ventricular ejection fraction, systolic blood pressure, and high values of hsTropI above 99th percentiles were independent in-hospital mortality predictors. The value of hsTropI at the time of admission was not associated with poor composite outcome during follow-up. However, patients who showed an increasing trend of hsTropI value at the time of discharge were found to have a significant increase in the composite outcome.

Conclusion

High-sensitivity troponin I is a valuable biomarker that can predict in-hospital mortality and long-term follow-up outcomes in patients with acute heart failure. It plays a crucial role in developing improved strategies for heart failure surveillance and management in the community.

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非急性冠状动脉综合征（Non-acute coronary syndrome，NCS）急性心力衰竭患者的高敏肌钙蛋白 I 与临床预后之间的关系 - 一项为期一年的随访研究。

研究的主要目的是调查非急性冠状动脉综合征（non-acute coronary syndrome，Non-ACS）急性心力衰竭患者住院期间高敏肌钙蛋白 I（hsTropI）水平与随访一年的预后结果之间的相关性。次要目标是评估指数住院期间急性心力衰竭的特征。方法入院和出院时均检测高敏肌钙蛋白 I 值。研究了入院时的高敏肌钙蛋白 I 值以及其他参数和风险因素与院内死亡率的相关性。对出院后指数住院患者进行了为期一年的随访，并记录了心血管死亡或因心力衰竭再次住院的复合终点。结果在350名患者中，38名（10.8%）患者在指数住院期间死亡，142名（46%）患者在随访期间出现综合结果。年龄、既往心衰病史、心房颤动、左心室射血分数低、收缩压和高于第99百分位数的高hsTropI值是独立的院内死亡率预测因素。入院时的 hsTropI 值与随访期间的不良综合预后无关。结论高敏肌钙蛋白 I 是一种有价值的生物标志物，可预测急性心力衰竭患者的院内死亡率和长期随访结果。高敏肌钙蛋白 I 是一种重要的生物标志物，可预测急性心力衰竭患者的院内死亡率和长期随访结果。

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来源期刊

Indian heart journal CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.60

自引率

6.70%

发文量

审稿时长

52 days

期刊介绍： Indian Heart Journal (IHJ) is the official peer-reviewed open access journal of Cardiological Society of India and accepts articles for publication from across the globe. The journal aims to promote high quality research and serve as a platform for dissemination of scientific information in cardiology with particular focus on South Asia. The journal aims to publish cutting edge research in the field of clinical as well as non-clinical cardiology - including cardiovascular medicine and surgery. Some of the topics covered are Heart Failure, Coronary Artery Disease, Hypertension, Interventional Cardiology, Cardiac Surgery, Valvular Heart Disease, Pulmonary Hypertension and Infective Endocarditis. IHJ open access invites original research articles, research briefs, perspective, case reports, case vignette, cardiovascular images, cardiovascular graphics, research letters, correspondence, reader forum, and interesting photographs, for publication. IHJ open access also publishes theme-based special issues and abstracts of papers presented at the annual conference of the Cardiological Society of India.