Surface dielectric resonator for in vivo EPR measurements

IF 2 3区化学 Q3 BIOCHEMICAL RESEARCH METHODS Journal of magnetic resonance Pub Date : 2024-05-01 DOI:10.1016/j.jmr.2024.107690

Sergey V. Petryakov , Maciej M. Kmiec , Conner S. Ubert , Victor B. Kassey , Philip E. Schaner , Periannan Kuppusamy

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Abstract

This research report describes a novel surface dielectric resonator (SDR) with a flexible connector for in vivo electron paramagnetic resonance (EPR) spectroscopy. Contrary to the conventional cavity or surface loop-gap resonators, the newly developed SDR is constructed from a ceramic dielectric material, and it is tuned to operate at the L-band frequency band (1.15 GHz) in continuous-wave mode. The SDR is designed to be critically coupled and capable of working with both very lossy samples, such as biological tissues, and non-lossy materials. The SDR was characterized using electromagnetic field simulations, assessed for sensitivity with a B₁ field-perturbation method, and validated with tissue phantoms using EPR measurements. The results showed remarkably higher sensitivity in lossy tissue phantoms than the previously reported multisegment surface-loop resonators. The new SDR can provide potential new insights for advancements in the application of in vivo EPR spectroscopy for biological measurements, including clinical oximetry.

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用于体内 EPR 测量的表面介质谐振器

本研究报告介绍了一种带柔性连接器的新型表面介质谐振器（SDR），用于体内电子顺磁共振（EPR）光谱分析。与传统的空腔或表面环隙谐振器不同，新开发的表面介质谐振器由陶瓷介质材料制成，可在 L 波段（1.15 GHz）以连续波模式工作。SDR 设计为临界耦合，既可用于生物组织等损耗很大的样品，也可用于非损耗材料。利用电磁场模拟对 SDR 进行了表征，采用 B1 场扰动方法对灵敏度进行了评估，并利用 EPR 测量对组织模型进行了验证。结果表明，在有损组织模型中的灵敏度明显高于之前报道的多段面环谐振器。新型 SDR 可为体内 EPR 光谱在生物测量（包括临床血氧测量）中的应用提供潜在的新见解。

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来源期刊

Journal of magnetic resonance 物理-光谱学

CiteScore

3.80

自引率

13.60%

发文量

150

审稿时长

69 days

期刊介绍： The Journal of Magnetic Resonance presents original technical and scientific papers in all aspects of magnetic resonance, including nuclear magnetic resonance spectroscopy (NMR) of solids and liquids, electron spin/paramagnetic resonance (EPR), in vivo magnetic resonance imaging (MRI) and spectroscopy (MRS), nuclear quadrupole resonance (NQR) and magnetic resonance phenomena at nearly zero fields or in combination with optics. The Journal''s main aims include deepening the physical principles underlying all these spectroscopies, publishing significant theoretical and experimental results leading to spectral and spatial progress in these areas, and opening new MR-based applications in chemistry, biology and medicine. The Journal also seeks descriptions of novel apparatuses, new experimental protocols, and new procedures of data analysis and interpretation - including computational and quantum-mechanical methods - capable of advancing MR spectroscopy and imaging.