The utility of endobronchial ultrasound‐guided transbronchial mediastinal cryobiopsy (EBUS‐TBMC) for the diagnosis of mediastinal lymphoma

IF 0.8 Q4 RESPIRATORY SYSTEM Respirology Case Reports Pub Date : 2024-04-01 DOI:10.1002/rcr2.1342

N. Huan, Wei Lun Lee, H. Ramarmuty, L. Nyanti, Melody Shu Ling Tsen, Dahziela Yunus

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Abstract

Abstract Endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA) is a revolutionary tool for the diagnosis and staging of mediastinal disorders. Nevertheless, its diagnostic capability is reduced in certain disorders such as lymphoproliferative diseases. EBUS‐guided transbronchial mediastinal cryobiopsy (EBUS‐TBMC) is a novel technique that can provide larger samples with preserved tissue architecture, with an acceptable safety profile. In this case report, we present a middle‐aged gentleman with a huge anterior mediastinal mass and bilateral mediastinal and hilar lymphadenopathy. He underwent EBUS‐TBNA with rapid on‐site evaluation (ROSE) followed by EBUS‐TBMC, all under general anaesthesia. Histopathological analysis showed discordance between EBUS‐TBNA and EBUS‐TBMC in which only TBMC samples provided adequate tissue to attain a diagnosis of primary mediastinal large B‐cell lymphoma. This case report reinforced the diagnostic role of EBUS‐TBMC in the diagnosis of lymphoproliferative diseases.

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支气管内超声引导下经支气管纵隔冷冻活组织检查（EBUS-TBMC）对纵隔淋巴瘤诊断的实用性

摘要支气管内超声引导下经支气管针吸术（EBUS-TBNA）是纵隔疾病诊断和分期的革命性工具。然而，它在某些疾病（如淋巴增生性疾病）中的诊断能力却有所下降。EBUS 引导下经支气管纵隔冷冻活组织检查（EBUS-TBMC）是一种新型技术，可提供较大的样本并保留组织结构，安全性也可接受。在本病例报告中，我们介绍了一位患有巨大前纵隔肿块和双侧纵隔及肺门淋巴结病的中年男性。他在全身麻醉下接受了 EBUS-TBNA 和快速现场评估（ROSE），随后又接受了 EBUS-TBMC。组织病理学分析表明，EBUS-TBNA 和 EBUS-TBMC 之间存在差异，只有 TBMC 样本提供的组织足以确诊为原发性纵隔大 B 细胞淋巴瘤。该病例报告加强了 EBUS-TBMC 在淋巴增生性疾病诊断中的作用。

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来源期刊

Respirology Case Reports RESPIRATORY SYSTEM-

CiteScore

1.40

自引率

0.00%

发文量

178

审稿时长

8 weeks

期刊介绍： Respirology Case Reports is an open-access online journal dedicated to the publication of original clinical case reports, case series, clinical images and clinical videos in all fields of respiratory medicine. The Journal encourages the international exchange between clinicians and researchers of experiences in diagnosing and treating uncommon diseases or diseases with unusual presentations. All manuscripts are peer-reviewed through a streamlined process that aims at providing a rapid turnaround time from submission to publication.