Management of atrial arrhythmias identified by cardiac devices

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-04-01 DOI:10.1093/eurheartjsupp/suae029
F. Stazi
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Abstract

Implantable cardiac devices have shown that atrial fibrillation (AF) is more frequent than previously assumed, with subclinical, asymptomatic, self-limiting manifestations called atrial high-rate events (AHREs) or subclinical AF. The clinical significance and correct therapeutic management of these episodes of subclinical AF is less well defined than in the case of clinically manifest AF. Two important randomized studies on the topic have recently been published, NOAH-AFNET 6 and ARTESIA, which, however, have not definitively clarified the topic. In patients with AHRE or subclinical AF, the average thrombo-embolic risk is lower than that in patients with clinically manifest AF and is ∼1%. For this reason, in these patients, the possibility that the benefit of anticoagulant therapy is overshadowed by the risk of bleeding is very high. Therefore, while waiting for new tools that allow a better stratification of low-risk patients, we must rely on individual clinical evaluation and overcome the qualitative dichotomy (AHRE yes vs. AHRE no), preferring instead an approach that is as quantitative as possible and takes into account the number of episodes, their duration, and the patient’s CHADSVASC score, before deciding, in each individual case, whether or not to use anticoagulant therapy.
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管理心脏设备识别的房性心律失常
植入式心脏设备表明,心房颤动(房颤)比以前假定的更为常见,其亚临床、无症状、自限性表现被称为心房高频事件(AHREs)或亚临床房颤。与临床表现的房颤相比,这些亚临床房颤发作的临床意义和正确的治疗方法尚不明确。最近发表了两项有关该主题的重要随机研究:NOAH-AFNET 6 和 ARTESIA,但这两项研究并未明确阐明该主题。在 AHRE 或亚临床房颤患者中,血栓栓塞的平均风险低于临床表现房颤患者,仅为 1%。因此,在这些患者中,抗凝治疗的益处被出血风险所掩盖的可能性非常高。因此,在等待能更好地对低风险患者进行分层的新工具的同时,我们必须依靠个体临床评估并克服定性二分法(AHRE 是与 AHRE 否),而更倾向于采用一种尽可能定量的方法,并考虑到发作次数、持续时间和患者的 CHADSVASC 评分,然后再根据每个病例的具体情况决定是否使用抗凝疗法。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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