Expert recommendations for pancreatitis/pancreatic necrosis treatment after L-asparaginase in children with acute lymphoblastic leukemia

T. T. Valiev, E. Kumirova, V. Rozinov, T. R. Panferova, I. Khvorostov, K. L. Kondratchik, O. Y. Fuks, P. A. Kerimov, N. Matinyan, A. N. Belyaeva, A. Efremenkov, A. A. Bystrova, A. P. Kurkin, V. V. Gorev
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Abstract

L-asparaginase is one of the most effective drugs in pediatric and adult acute lymphoblastic leukemia treatment. But drug side effects are an important problem. pancreatitis and pancreatic necrosis are not common (2–18 %) complication, but high chance of severe disease with fatal outcome make to bring in careful attention of pediatric oncologists-hematologists, surgeons, intensivists, radiologists. Recognizing multidisciplinary importance of this problem, at June 21st, 2023 at Morozov Children’s Clinical hospital a Round table on pancreatitis/pancreatic necrosis after L-asparaginase use was organized. This article presents expert recommendations from federal and regional clinics in diagnosis and treatment of such severe complication.
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急性淋巴细胞白血病患儿使用 L-天冬酰胺酶治疗胰腺炎/胰腺坏死的专家建议
L-天冬酰胺酶是治疗儿童和成人急性淋巴细胞白血病最有效的药物之一。胰腺炎和胰腺坏死并不是常见的并发症(2%-18%),但严重疾病导致致命后果的几率很高,因此需要儿科肿瘤专家--血液科专家、外科医生、重症监护专家和放射科专家的密切关注。认识到这一问题的多学科重要性,2023 年 6 月 21 日在莫罗佐夫儿童临床医院组织了一次关于使用 L-天冬酰胺酶后胰腺炎/胰腺坏死的圆桌会议。本文介绍了联邦和地区诊所在诊断和治疗此类严重并发症方面的专家建议。
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