The point on the treatment of arrhythmic storm

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-04-01 DOI:10.1093/eurheartjsupp/suae016
Ludovico Lazzari, S. Donzelli, A. Tordini, Antonio Parise, Ciro Pirozzi, Federica Di Meo, Carmine Marallo, Vincenzo Pace, C. Marini, Giovanni Carreras
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Abstract

Arrhythmic storm is a clinical emergency associated with high mortality, which requires multi-disciplinary management. Reprogramming of the implantable cardiac defibrillator (ICD) aimed at reducing shocks, adrenergic blockade using beta-blockers, sedation/anxiolysis, and blockade of the stellate ganglion represent the first simple and effective manoeuvres, but further suppression of arrhythmias with antiarrhythmics is often required. A low-risk patient (e.g. monomorphic ventricular tachycardia, functioning ICD, and haemodynamically stable) should be managed with a beta-blocker (possibly non-selective) plus amiodarone, in addition to sedation with a benzodiazepine or dexmedetomidine; in patients at greater risk (high burden and haemodynamic instability), autonomic modulation with blockade of the stellate ganglion and the addition of a second antiarrhythmic (lidocaine) should be considered. In patients refractory to these measures, with advanced heart failure, general anaesthesia with intubation and the establishment of a haemodynamic circulatory support should be considered. Ablation, performed early, appears to be superior in terms of mortality and reduction of future shocks compared with titration of antiarrhythmics.
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心律失常风暴的治疗要点
心律失常风暴是一种与高死亡率相关的临床急症,需要多学科管理。对植入式心脏除颤器(ICD)进行重新编程以减少冲击、使用β-受体阻滞剂阻断肾上腺素、镇静/抗焦虑以及阻断星状神经节,这些都是简单有效的初步措施,但通常还需要使用抗心律失常药物进一步抑制心律失常。对于低风险患者(如单形室性心动过速、ICD 功能正常、血流动力学稳定),除了使用苯二氮卓类药物或右美托咪定镇静外,还应使用β-受体阻滞剂(可能是非选择性的)加胺碘酮;对于高风险患者(高负担和血流动力学不稳定),应考虑通过阻滞星状神经节来调节自律神经,并使用第二种抗心律失常药物(利多卡因)。对这些措施无效的晚期心力衰竭患者,应考虑进行插管全身麻醉,并建立血流动力学循环支持。与滴定抗心律失常药物相比,早期进行消融治疗在降低死亡率和减少未来电击方面似乎更有优势。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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