Biomimetic Integrated Nanozyme for Flare and Recurrence of Gouty Arthritis

IF 10.7 1区 医学 Q1 PHARMACOLOGY & PHARMACY Asian Journal of Pharmaceutical Sciences Pub Date : 2024-06-01 DOI:10.1016/j.ajps.2024.100913
Rui Wang , Tongyao Liu , Xinhong Li , Enhao Lu , Yiting Chen , Kuankuan Luo , Tao Wang , Xueli Huang , Zhiwen Zhang , Shilin Du , Xianyi Sha
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Abstract

Flare and multiple recurrences pose significant challenges in gouty arthritis. Traditional treatments provide temporary relief from inflammation but fail to promptly alleviate patient pain or effectively prevent subsequent recurrences. It should also be noted that both anti-inflammation and metabolism of uric acid are necessary for gouty arthritis, calling for therapeutic systems to achieve these two goals simultaneously. In this study, we propose a biomimetic integrated nanozyme, HMPB-Pt@MM, comprising platinum nanozyme and hollow Prussian blue. It demonstrates anti-inflammatory properties by eliminating reactive oxygen species and reducing infiltration of inflammatory macrophages. Additionally, it rapidly targets inflamed ankles through the camouflage of macrophage membranes. Furthermore, HMPB-Pt@MM exhibits urate oxidase-like capabilities, continuously metabolizing locally elevated uric acid concentrations, ultimately inhibiting multiple recurrences of gouty arthritis. In summary, HMPB-Pt@MM integrates ROS clearance with uric acid metabolism, offering a promising platform for the treatment of gouty arthritis.

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治疗痛风性关节炎发作和复发的生物仿生集成纳米酶
痛风性关节炎的发作和多次复发给患者带来了巨大的挑战。传统治疗方法能暂时缓解炎症,但无法及时减轻患者的痛苦,也无法有效预防后续复发。还需要注意的是,痛风性关节炎需要抗炎和尿酸代谢,这就要求治疗系统同时实现这两个目标。在这项研究中,我们提出了一种生物仿生集成纳米酶 HMPB-Pt@MM,由铂纳米酶和中空普鲁士蓝组成。它具有抗炎特性,能消除活性氧,减少炎性巨噬细胞的浸润。此外,它还能通过伪装巨噬细胞膜,迅速锁定发炎的脚踝。此外,HMPB-Pt@MM 还具有类似尿酸氧化酶的能力,可持续代谢局部升高的尿酸浓度,最终抑制痛风性关节炎的多次复发。总之,HMPB-Pt@MM 将清除 ROS 与尿酸代谢结合在一起,为痛风性关节炎的治疗提供了一个前景广阔的平台。
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来源期刊
Asian Journal of Pharmaceutical Sciences
Asian Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
18.30
自引率
2.90%
发文量
11
审稿时长
14 days
期刊介绍: The Asian Journal of Pharmaceutical Sciences (AJPS) serves as the official journal of the Asian Federation for Pharmaceutical Sciences (AFPS). Recognized by the Science Citation Index Expanded (SCIE), AJPS offers a platform for the reporting of advancements, production methodologies, technologies, initiatives, and the practical application of scientific knowledge in the field of pharmaceutics. The journal covers a wide range of topics including but not limited to controlled drug release systems, drug targeting, physical pharmacy, pharmacodynamics, pharmacokinetics, pharmacogenomics, biopharmaceutics, drug and prodrug design, pharmaceutical analysis, drug stability, quality control, pharmaceutical engineering, and material sciences.
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