Soluble αKlotho concentration in the inferior vena cava of patients with primary aldosteronism

IF 2 4区医学 Q2 UROLOGY & NEPHROLOGY Nefrologia Pub Date : 2024-09-01 DOI:10.1016/j.nefro.2024.04.001

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Abstract

Introduction

Klotho, a key aging regulator, is predominantly expressed in the kidney. Various methods now enable the measurement of soluble αKlotho blood levels in humans. Limited studies have explored the renal origin of circulating αKlotho in humans.

Methods

Soluble αKlotho in the inferior vena cava blood was measured using an enzyme-linked immunosorbent assay kit using blood samples from patients undergoing adrenal venous catheterization for close examination of primary aldosteronism.

Results

The concentration at the suprarenal inferior vena cava (476 ± 68.2) was significantly higher than that at the infrarenal inferior vena cava (434 ± 74.8) (p = 0.018), with a rate of change of 8.12 (2.3)%.

Conclusions

We demonstrate a step-up in αKlotho concentration from the infrarenal to suprarenal vena cava in humans, supporting the kidney's origin of soluble αKlotho in the bloodstream.

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原发性醛固酮增多症患者下腔静脉中的可溶性αKlotho浓度

导言Klotho是一种关键的衰老调节因子，主要在肾脏中表达。目前有多种方法可以测量人体血液中的可溶性αKlotho水平。方法使用酶联免疫吸附测定试剂盒测量下腔静脉血中可溶性αKlotho的含量，采用的血液样本来自接受肾上腺静脉导管插入术以仔细检查原发性醛固酮增多症的患者。2）明显高于肾下腔静脉（434 ± 74.8）（p = 0.018），变化率为 8.12 (2.3)%。结论我们证明了人体αKlotho浓度从肾下腔静脉到肾上腔静脉呈阶梯式上升，支持肾脏是血液中可溶性αKlotho的来源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nefrologia 医学-泌尿学与肾脏学

CiteScore

3.40

自引率

7.70%

发文量

148

审稿时长

47 days

期刊介绍： Nefrología is the official publication of the Spanish Society of Nephrology. The Journal publishes articles on basic or clinical research relating to nephrology, arterial hypertension, dialysis and kidney transplants. It is governed by the peer review system and all original papers are subject to internal assessment and external reviews. The journal accepts submissions of articles in English and in Spanish languages.