Telmisartan-Induced Myotoxicity in Patients with Essential Hypertension.

Suleyman Cihan Kara, U. Canpolat
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Abstract

Drug-related muscular adverse effects are relatively common among certain groups of drugs, such as statins and steroids. However, these adverse effects are less well-known for angiotensin receptor blockers (ARBs). It is proposed that telmisartan and irbesartan may cause myotoxicity via increased Peroxisome Proliferator-Activated Receptor gamma (PPAR-gamma) activity. Herein, we present two hypertensive patients in whom telmisartan-induced myotoxicity was observed. Therefore, physicians should be aware that telmisartan, along with some other ARBs, can also cause myopathy. Possible drug-drug interactions should be considered in cases of concomitant prescription of these agents with other myopathic drugs.
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替米沙坦诱发重度高血压患者的肌毒性
与药物有关的肌肉不良反应在他汀类药物和类固醇类药物等某些药物中比较常见。然而,血管紧张素受体阻滞剂(ARB)的这些不良反应却鲜为人知。有人提出,替米沙坦和厄贝沙坦可能会通过增加过氧化物酶体增殖激活受体γ(PPAR-γ)的活性而导致肌毒性。在此,我们介绍了两名观察到替米沙坦诱发肌毒性的高血压患者。因此,医生应注意替米沙坦和其他一些ARBs也可能导致肌病。在同时处方这些药物和其他肌病药物时,应考虑可能存在的药物相互作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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