Highly Sensitive SPR Biosensor for Malaria Detection Employing ZnO, Fe2O3, and Black Phosphorous

IF 3.3 4区物理与天体物理 Q2 CHEMISTRY, PHYSICAL Plasmonics Pub Date : 2024-04-27 DOI:10.1007/s11468-024-02307-3

Nikhil Pratap Singh, Adarsh Chandra Mishra, Sapana Yadav, Pooja Lohia, D. K. Dwivedi, M. Khalid Hossain

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Abstract

A highly sensitive surface plasmon resonance biosensor employing BK7 prism, Silver (Ag), zinc oxide (ZnO), ferromagnetic material (Fe₂O₃), and two-dimensional (2D) nanomaterial black phosphorous (BP) has been proposed. Thin layers of two different oxide layers sandwiched between Ag and BP in Kretschmann configuration. The angular interrogation method–based numerical simulation is applied for modelling of high performance SPR biosensor at a wavelength of 633 nm (visible region). Transfer matrix method and finite element methods have been used to obtain [performance parameters. This sensor can detect malaria at different stages and provides a large range of refractive index (RI) sensing from 1.369 to 1.409. The RI for malaria stages, including the ring, trophozoite, and schizont stages, are 1.396, 1.381, and 1.371 respectively, with corresponding angular sensitivities of 367 deg/RIU, 297 deg/RIU, and 269 deg/RIU. The sensor offers an ultrahigh angular sensitivity for malaria detection in ring stage. This research could pave the way for an important bio sample detection apparatus that allows for quick and precise in ring stage diagnosis.

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利用氧化锌、氧化铁和黑磷检测疟疾的高灵敏度 SPR 生物传感器

我们提出了一种高灵敏度的表面等离子体共振生物传感器，它采用了 BK7 棱镜、银（Ag）、氧化锌（ZnO）、铁磁材料（Fe2O3）和二维（2D）纳米材料黑磷（BP）。在 Kretschmann 配置中，两种不同氧化物薄层夹在 Ag 和 BP 之间。基于角度询问法的数值模拟被应用于波长为 633 nm（可见光区域）的高性能 SPR 生物传感器的建模。利用传递矩阵法和有限元法获得了[性能参数]。该传感器可检测不同阶段的疟疾，并提供从 1.369 到 1.409 的大范围折射率 (RI) 检测。疟疾阶段（包括环形、滋养体和分裂体阶段）的折射率分别为 1.396、1.381 和 1.371，相应的角度灵敏度分别为 367 度/RIU、297 度/RIU 和 269 度/RIU。该传感器具有超高的角度灵敏度，可用于环形疟疾检测。这项研究可为一种重要的生物样本检测仪器铺平道路，该仪器可实现快速、精确的环期诊断。

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来源期刊

Plasmonics 工程技术-材料科学：综合

CiteScore

5.90

自引率

6.70%

发文量

164

审稿时长

2.1 months

期刊介绍： Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.