LncRNA STARD7-AS1 suppresses cervical cancer cell proliferation while promoting autophagy by regulating miR-31-5p/TXNIP axis to inactivate the mTOR signaling.

IF 3.4 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Journal of Gynecologic Oncology Pub Date : 2024-04-19 DOI:10.3802/jgo.2024.35.e97
Xiyao Yin, Xin Liu, Hui Gong, Zhiliang Chu
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Abstract

Cervical cancer (CC) is a serious gynecologic health issue for women worldwide. Long non-coding RNA (lncRNA) has been well-documented in controlling malignant behavior of various cancer cells. The role of lncRNA STARD7-AS1 in regulating CC cell proliferation and autophagy and its possible mechanism were investigated in this work.
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LncRNA STARD7-AS1 通过调节 miR-31-5p/TXNIP 轴,使 mTOR 信号失活,从而在抑制宫颈癌细胞增殖的同时促进自噬。
宫颈癌(CC)是全球妇女面临的一个严重的妇科健康问题。长非编码 RNA(lncRNA)在控制各种癌细胞的恶性行为方面已被充分证明。本研究探讨了lncRNA STARD7-AS1在调控CC细胞增殖和自噬中的作用及其可能的机制。
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来源期刊
Journal of Gynecologic Oncology
Journal of Gynecologic Oncology ONCOLOGY-OBSTETRICS & GYNECOLOGY
CiteScore
6.00
自引率
2.60%
发文量
84
审稿时长
>12 weeks
期刊介绍: The Journal of Gynecologic Oncology (JGO) is an official publication of the Asian Society of Gynecologic Oncology. Abbreviated title is ''J Gynecol Oncol''. It was launched in 1990. The JGO''s aim is to publish the highest quality manuscripts dedicated to the advancement of care of the patients with gynecologic cancer. It is an international peer-reviewed periodical journal that is published bimonthly (January, March, May, July, September, and November). Supplement numbers are at times published. The journal publishes editorials, original and review articles, correspondence, book review, etc.
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