The Genetics of Human Sleep and Sleep Disorders

IF 7.7 2区 生物学 Q1 GENETICS & HEREDITY Annual review of genomics and human genetics Pub Date : 2024-04-26 DOI:10.1146/annurev-genom-121222-120306
Xianlin Zou, Louis J. Ptáček, Ying-Hui Fu
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Abstract

Healthy sleep is vital for humans to achieve optimal health and longevity. Poor sleep and sleep disorders are strongly associated with increased morbidity and mortality. However, the importance of good sleep continues to be underrecognized. Mechanisms regulating sleep and its functions in humans remain mostly unclear even after decades of dedicated research. Advancements in gene sequencing techniques and computational methodologies have paved the way for various genetic analysis approaches, which have provided some insights into human sleep genetics. This review summarizes our current knowledge of the genetic basis underlying human sleep traits and sleep disorders. We also highlight the use of animal models to validate genetic findings from human sleep studies and discuss potential molecular mechanisms and signaling pathways involved in the regulation of human sleep.
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人类睡眠和睡眠障碍的遗传学
健康的睡眠对人类实现最佳健康和长寿至关重要。睡眠不足和睡眠障碍与发病率和死亡率的增加密切相关。然而,良好睡眠的重要性仍未得到充分认识。即使经过数十年的潜心研究,调节人类睡眠及其功能的机制大多仍不清楚。基因测序技术和计算方法的进步为各种遗传分析方法铺平了道路,为人类睡眠遗传学提供了一些见解。本综述总结了我们目前对人类睡眠特征和睡眠障碍的遗传基础的认识。我们还重点介绍了利用动物模型验证人类睡眠研究遗传发现的方法,并讨论了参与人类睡眠调节的潜在分子机制和信号通路。
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来源期刊
CiteScore
14.90
自引率
1.10%
发文量
29
期刊介绍: Since its inception in 2000, the Annual Review of Genomics and Human Genetics has been dedicated to showcasing significant developments in genomics as they pertain to human genetics and the human genome. The journal emphasizes genomic technology, genome structure and function, genetic modification, human variation and population genetics, human evolution, and various aspects of human genetic diseases, including individualized medicine.
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