Optimized Nanoscale Mineralization Strategy for Maintaining Bio-enzymatic Stability

IF 2.7 4区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Journal of Cluster Science Pub Date : 2024-04-27 DOI:10.1007/s10876-024-02624-x

Yingying Li, Jiahao Li, Jialiang Li, Yuntian Yan, Yan Zhao, Weiheng Kong, Fengli Qu

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Abstract

Conventional biomineralization strategies are constructed using microparticles, suffering the inhibition of protease bio-availability and required rigorous bio-evaluation. The use of nanomineralization technology could apply control over the size, shape, and composition of the materials and provide a steadier maintenance environment for the bio-enzyme. In this study, stable and nanoscale copper phosphate (Cu₃(PO₄)₂) bio-nanomineralization materials were constructed to encapsulate free bio-enzyme. By optimizing the biomineralization process, Cu₃(PO₄)₂ was demonstrated to enable the facile coordination of various bio-enzymes (e.g., catalase or β-glucosidase) for efficient bio-enzyme transportation and maintaining the bio-enzyme activity in harsh condition. The current nanomineralization strategy could provide new ideas and methods for the development of biocatalysis, biosensing, biomedicine, and other related fields.

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保持生物酶稳定性的优化纳米级矿化策略

传统的生物矿化策略是利用微颗粒构建的，会抑制蛋白酶的生物利用率，需要进行严格的生物评估。使用纳米矿化技术可以控制材料的大小、形状和成分，为生物酶提供更稳定的维持环境。本研究构建了稳定的纳米级磷酸铜（Cu3(PO4)2）生物纳米矿化材料，用于封装游离生物酶。通过优化生物纳米化过程，Cu3(PO4)2 可与多种生物酶（如过氧化氢酶或β-葡萄糖苷酶）轻松配位，从而实现生物酶的高效运输，并在苛刻条件下保持生物酶的活性。目前的纳米矿化策略可为生物催化、生物传感、生物医学及其他相关领域的发展提供新的思路和方法。

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来源期刊

Journal of Cluster Science 化学-无机化学与核化学

CiteScore

6.70

自引率

0.00%

发文量

166

审稿时长

3 months

期刊介绍： The journal publishes the following types of papers: (a) original and important research; (b) authoritative comprehensive reviews or short overviews of topics of current interest; (c) brief but urgent communications on new significant research; and (d) commentaries intended to foster the exchange of innovative or provocative ideas, and to encourage dialogue, amongst researchers working in different cluster disciplines.