Factors related to nocturia-specific quality of life in renal transplantation patients

IF 1.5 4区医学 Q3 UROLOGY & NEPHROLOGY LUTS: Lower Urinary Tract Symptoms Pub Date : 2024-05-01 DOI:10.1111/luts.12517

Nobuyuki Nakamura, Taiki Emoto, Yuichiro Fukuhara, Takeshi Miyazaki, Chikao Aoyagi, Naotaka Gunge, Yu Okabe, Hiroshi Matsuzaki, Aiko Fujikawa, Chizuru Nakagawa, Masahiro Tachibana, Fumihiro Yamasaki, Kosuke Tominaga, Kazuna Tsubouchi, Shintaro Aso, Nobuhiro Haga

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Abstract

Objectives

Patients following renal transplantation (RTX) may experience nocturia exacerbation due to polyuria and reduced bladder capacity, thereby impacting the specific quality of life (QOL) associated with nocturia. The present study aims to investigate factors associated with the deterioration of nocturia-specific QOL in RTX patients.

Methods

The study cohort comprised 59 consecutive patients who had undergone successful RTX. Nocturia-related QOL questionnaires (N-QOL) were employed to evaluate the specific QOL related to nocturia. The Bother/Concern and Sleep/Energy domains of the N-QOL were also assessed. The primary outcome measure was to explore factors related to the aggravation of nocturia-specific QOL in patients post-RTX.

Results

The mean nocturia frequency post-RTX was 1.3 ± 1.0. Univariate and multivariate analyses revealed a significant reduction in the Bother/Concern domain score associated with increased nocturia (p = .042). Aging significantly decreased the total N-QOL score and the Sleep/Energy domain score (p = .001 and .0002, respectively). Prolonged duration after RTX significantly reduced the scores of both the Sleep/Energy domain and the Bother/Concern domain (p = .018 and .037, respectively). However, the duration of dialysis prior to RTX was not significantly associated with the total score or subdomains of N-QOL.

Conclusions

Nocturia-specific QOL affected not only the nocturia itself, but also aging and the prolonged duration after RTX. Thus, comprehensive approaches to the RTX patients were needed to improve the Nocturia-specific QOL in RTX patients.

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肾移植患者夜尿症生活质量的相关因素

目的肾移植（RTX）术后患者可能会因为多尿和膀胱容量减少而导致夜尿加重，从而影响与夜尿相关的特定生活质量（QOL）。本研究旨在探讨与 RTX 患者夜尿特异性 QOL 恶化相关的因素。方法研究队列包括 59 名成功接受 RTX 的连续患者。采用夜尿相关 QOL 问卷（N-QOL）评估与夜尿相关的特异性 QOL。此外，还对 N-QOL 的 "烦扰/担忧 "和 "睡眠/能量 "领域进行了评估。主要研究结果是探讨 RTX 术后患者夜尿特异性 QOL 恶化的相关因素。结果 RTX术后的平均夜尿次数为1.3±1.0次。单变量和多变量分析显示，Bother/Concern域得分的显著降低与夜尿次数增加有关（p = .042）。年龄增长会明显降低 N-QOL 总分和睡眠/能量域得分（p = .001 和 .0002）。RTX 后透析时间延长会明显降低睡眠/能量域和烦恼/忧虑域的得分（p = .018 和 .037）。但是，RTX 之前的透析持续时间与 N-QOL 的总分或子域没有明显关系。结论夜尿症特异性 QOL 不仅影响夜尿症本身，还影响年龄增长和 RTX 后的持续时间。因此，需要对 RTX 患者采取综合方法，以改善 RTX 患者夜尿特异性 QOL。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

LUTS: Lower Urinary Tract Symptoms UROLOGY & NEPHROLOGY-

CiteScore

3.00

自引率

7.70%

发文量

审稿时长

>12 weeks

期刊介绍： LUTS is designed for the timely communication of peer-reviewed studies which provides new clinical and basic science information to physicians and researchers in the field of neurourology, urodynamics and urogynecology. Contributions are reviewed and selected by a group of distinguished referees from around the world, some of whom constitute the journal''s Editorial Board. The journal covers both basic and clinical research on lower urinary tract dysfunctions (LUTD), such as overactive bladder (OAB), detrusor underactivity, benign prostatic hyperplasia (BPH), bladder outlet obstruction (BOO), urinary incontinence, pelvic organ prolapse (POP), painful bladder syndrome (PBS), as well as on other relevant conditions. Case reports are published only if new findings are provided. LUTS is an official journal of the Japanese Continence Society, the Korean Continence Society, and the Taiwanese Continence Society. Submission of papers from all countries are welcome. LUTS has been accepted into Science Citation Index Expanded (SCIE) with a 2011 Impact Factor.