Imaging biomacromolecules in action with liquid-phase electron microscopy

IF 14 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Trends in Chemistry Pub Date : 2024-05-03 DOI:10.1016/j.trechm.2024.04.004
Jia-ye Li, He Sun, Huan Wang
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Abstract

Imaging biomacromolecules in action in a liquid environment poses a challenge to single-molecule experiments. Liquid-phase electron microscopy (LP-EM) has demonstrated its unique ability to reveal previously unseen transient dynamics and intermediate states of delicate biomacromolecular systems (protein, DNA/RNA) with deep-learning methods and careful evaluation of electron beam effects.

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利用液相电子显微镜对生物大分子的作用进行成像
对液体环境中的生物大分子进行成像是单分子实验面临的一项挑战。液相电子显微镜(LP-EM)通过深度学习方法和对电子束效应的仔细评估,展示了其独特的能力,可以揭示微妙的生物分子系统(蛋白质、DNA/RNA)以前从未见过的瞬态动力学和中间状态。
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来源期刊
Trends in Chemistry
Trends in Chemistry CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
28.00
自引率
0.60%
发文量
138
期刊介绍: Trends in Chemistry serves as a new global platform for discussing significant and transformative concepts across all areas of chemistry. It recognizes that breakthroughs in chemistry hold the key to addressing major global challenges. The journal offers readable, multidisciplinary articles, including reviews, opinions, and short pieces, designed to keep both students and leading scientists updated on pressing issues in the field. Covering analytical, inorganic, organic, physical, and theoretical chemistry, the journal highlights major themes such as biochemistry, catalysis, environmental chemistry, materials, medicine, polymers, and supramolecular chemistry. It also welcomes articles on chemical education, health and safety, policy and public relations, and ethics and law.
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