Innate phase production of IFN-γ by memory and effector T cells expressing early activation marker CD69 during infection with Cryptococcus deneoformans in the lungs
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引用次数: 0
Abstract
The two sister species, Cryptococcus neoformans (formerly C. neoformans var. grubii, serotype A) and C. deneoformans (formerly C. neoformans var. neoformans, serotype D), are yeast-type fungal pathogens characterized by thick capsules composed
of polysaccharides such as glucuronoxylomannan and galactoxylomannan (1). These fungi grow in pigeon droppings and enter the lungs via an airborne route.
While most healthy individuals experience asymptomatic infection, marked by granulomatous
lesions in the lungs caused by these fungi, immunocompromised hosts with severely
impaired cellular immunity, such as those with AIDS, frequently suffer from severe
lung lesions and disseminated infections that extend to the central nervous system
(2).
肺部感染隐球菌期间，表达早期活化标记 CD69 的记忆性和效应 T 细胞产生 IFN-γ 的先天期效应
这两个姊妹种，即新生隐球菌（原名 C. neoformans var. grubii，血清型 A）和 C. deneoformans（原名 C. neoformans var. neoformans，血清型 D），是酵母型真菌病原体，其特征是由葡萄糖醛酸甘露聚糖和半乳糖醛酸甘露聚糖等多糖组成的厚荚膜 (1)。这些真菌生长于鸽子粪便中，通过空气传播途径进入肺部。虽然大多数健康人在感染后无症状，肺部出现由这些真菌引起的肉芽肿，但细胞免疫功能严重受损的免疫功能低下的宿主，如艾滋病患者，经常会出现严重的肺部病变和扩展到中枢神经系统的播散性感染（2）。
期刊介绍：
Infection and Immunity (IAI) provides new insights into the interactions between bacterial, fungal and parasitic pathogens and their hosts. Specific areas of interest include mechanisms of molecular pathogenesis, virulence factors, cellular microbiology, experimental models of infection, host resistance or susceptibility, and the generation of innate and adaptive immune responses. IAI also welcomes studies of the microbiome relating to host-pathogen interactions.
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