Subclinical joint inflammation in rheumatoid arthritis: comparing thermal and ultrasound imaging at the metacarpophalangeal joint

IF 2 4区 医学 Q3 RHEUMATOLOGY Advances in Rheumatology Pub Date : 2024-05-03 DOI:10.1186/s42358-024-00377-9
York Kiat Tan, Gek Hsiang Lim
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Abstract

While ultrasound and MRI are both superior to clinical examination in the detection of joint inflammation, there is presently a lack of data whether thermography may be similarly useful in the assessment of joint inflammation in patients with RA. Our study aims to evaluate the use of thermography in detecting subclinical joint inflammation at clinically quiescent (non-tender and non-swollen) metacarpophalangeal joints (MCPJs) in patients with rheumatoid arthritis (RA). The outcomes from thermography in our study will be compared with ultrasonography (which is a more established imaging tool used for joint inflammation assessment in RA). The minimum (Tmin), average (Tavg) and maximum (Tmax) temperatures at the 10 MCPJs of each patient were summed to obtain the Total Tmin, Total Tavg and Total Tmax, respectively. Ultrasound grey-scale (GS) and power Doppler (PD) joint inflammation (scored semi-quantitatively, 0–3) at the 10 MCPJs were summed up to derive the respective TGS and TPD scores per patient. Pearson’s correlation and simple linear regression were respectively used to assess correlation and characterize relationships between thermographic parameters (Total Tmin, Total Tavg and Total Tmax) and ultrasound imaging parameters (TGS, TPD and the number of joint(s) with PD ≥ 1 or GS ≥ 2). In this cross-sectional study, 420 clinically non-swollen and non-tender MCPJs from 42 RA patients were examined. All thermographic parameters (Total Tmin, Total Tavg and Total Tmax) correlated significantly (P-values ranging from 0.001 to 0.0012) with TGS score (correlation coefficient ranging from 0.421 to 0.430), TPD score (correlation coefficient ranging from 0.383 to 0.424), and the number of joint(s) with PD ≥ 1 or GS ≥ 2 (correlation coefficient ranging from 0.447 to 0.465). Similarly, simple linear regression demonstrated a statistically significant relationship (P-values ranging from 0.001 to 0.005) between all thermographic parameters (Total Tmin, Total Tavg and Total Tmax) and ultrasound imaging parameters (TPD and TGS). For the first time, thermographic temperatures were shown to correlate with ultrasound-detected joint inflammation at clinically quiescent MCPJs. The use of thermography in the detection of subclinical joint inflammation in RA appears promising and warrants further investigation.
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类风湿性关节炎的亚临床关节炎症:掌指关节热成像与超声波成像的比较
虽然超声波和核磁共振成像在检测关节炎症方面均优于临床检查,但目前尚缺乏数据显示热成像在评估RA患者关节炎症方面是否同样有用。我们的研究旨在评估热成像技术在检测类风湿关节炎(RA)患者临床静止期(无触痛和无肿胀)掌指关节(MCPJ)亚临床关节炎症中的应用。我们研究中的热成像结果将与超声波成像(用于评估类风湿性关节炎关节炎症的更成熟的成像工具)进行比较。将每位患者 10 个 MCPJ 的最低温度(Tmin)、平均温度(Tavg)和最高温度(Tmax)相加,分别得出总 Tmin、总 Tavg 和总 Tmax。将 10 个 MCPJ 的超声灰度(GS)和功率多普勒(PD)关节炎症(半定量评分,0-3 分)相加,得出每位患者各自的 TGS 和 TPD 分数。皮尔逊相关性和简单线性回归分别用于评估热成像参数(总Tmin、总Tavg和总Tmax)与超声成像参数(TGS、TPD和PD≥1或GS≥2的关节数)之间的相关性和特征。在这项横断面研究中,对 42 名 RA 患者的 420 个临床无肿胀、无触痛的 MCPJ 关节进行了检查。所有热成像参数(总 Tmin、总 Tavg 和总 Tmax)均与 TGS 评分(相关系数为 0.421 至 0.430)、TPD 评分(相关系数为 0.383 至 0.424)以及 PD ≥ 1 或 GS ≥ 2 的关节数量(相关系数为 0.447 至 0.465)显著相关(P 值为 0.001 至 0.0012)。同样,简单线性回归显示,所有热成像参数(总 Tmin、总 Tavg 和总 Tmax)与超声成像参数(TPD 和 TGS)之间均存在显著的统计学关系(P 值范围为 0.001 至 0.005)。该研究首次证明,热成像温度与超声波检测到的临床静止 MCPJ 关节炎症相关。热成像技术在检测RA亚临床关节炎症方面的应用前景广阔,值得进一步研究。
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来源期刊
Advances in Rheumatology
Advances in Rheumatology Medicine-Rheumatology
CiteScore
4.00
自引率
4.30%
发文量
41
审稿时长
53 weeks
期刊介绍: Formerly named Revista Brasileira de Reumatologia, the journal is celebrating its 60th year of publication. Advances in Rheumatology is an international, open access journal publishing pre-clinical, translational and clinical studies on all aspects of paediatric and adult rheumatic diseases, including degenerative, inflammatory and autoimmune conditions. The journal is the official publication of the Brazilian Society of Rheumatology and welcomes original research (including systematic reviews and meta-analyses), literature reviews, guidelines and letters arising from published material.
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