Safety, Pharmacokinetics, Biomarker Response, and Efficacy of E6742, a Dual Antagonist of Toll-Like Receptors 7 and 8, in a First-in-Patient, Randomized, Double-Blind, Phase 1/2 Study in Systemic Lupus Erythematosus

medRxiv - Rheumatology Pub Date : 2024-04-27 DOI:10.1101/2024.04.26.24306410

Yoshiya Tanaka, Atsushi Kumanogoh, Tatsuya Atsumi, Tomonori Ishii, Fumitoshi Tago, Mari Aoki, Shintaro Yamamuro, Shizuo Akira

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Abstract

Objectives To evaluate the safety, tolerability, pharmacokinetics (PK), biomarker response, and efficacy of E6742 in a phase 1/2 study in patients with systemic lupus erythematosus (SLE).

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在一项针对系统性红斑狼疮的首例患者、随机、双盲、1/2 期研究中，Toll-Like 受体 7 和 8 双拮抗剂 E6742 的安全性、药代动力学、生物标志物反应和疗效

目的在一项针对系统性红斑狼疮 (SLE) 患者的 1/2 期研究中，评估 E6742 的安全性、耐受性、药代动力学 (PK)、生物标志物反应和疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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medRxiv - Rheumatology

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