Gold Nanoparticles Confined in Mesoporous Bioactive Glass for Periodontitis Therapy

IF 5.4 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Biomaterials Science & Engineering Pub Date : 2024-05-03 DOI:10.1021/acsbiomaterials.4c00107

Dong Zhou, Min Ge, QiHui Wang, Jingru Sun, Haiyan Yao, Yunyun Deng, Lan Xiao, Jiaolong Wang* and Junchao Wei*,

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Abstract

Periodontitis is a chronic disease caused by bacterial infection and is characterized with alveolar bone resorption. Bone regeneration in periodontitis remains a critical challenge because bacterial infection induced an unfavorable microenvironment for osteogenesis. Therefore, it is necessary to design proper therapeutic platforms to control bacterial infection and promote bone regeneration. Herein, mesoporous bioactive glass (MBG) with different pore sizes (3.0, 4.3, and 12.3 nm) was used as an in situ reactor to confine the growth of gold nanoparticles (Au NPs), forming MBG@Au hybrids which combine the osteoconductivity of MBG and antibacterial properties of Au NPs. Upon near-infrared (NIR) irradiation, the MBG@Au NPs showed efficient antibacterial properties both in vitro and in vivo. Besides, the osteogenesis properties of MBG@Au also improved under NIR irradiation. Furthermore, the in vivo results demonstrated that MBG@Au can effectively promote alveolar bone regeneration and realize the healing of serious periodontitis.

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用于牙周炎治疗的介孔生物活性玻璃中的纳米金粒子

牙周炎是一种由细菌感染引起的慢性疾病，以牙槽骨吸收为特征。由于细菌感染会诱发不利于骨生成的微环境，因此牙周炎的骨再生仍然是一项严峻的挑战。因此，有必要设计适当的治疗平台来控制细菌感染和促进骨再生。在此，研究人员使用不同孔径（3.0、4.3 和 12.3 nm）的介孔生物活性玻璃（MBG）作为原位反应器，限制金纳米粒子（Au NPs）的生长，形成 MBG@Au 混合物，该混合物结合了 MBG 的骨传导性和 Au NPs 的抗菌特性。在近红外（NIR）照射下，MBG@Au NPs 在体外和体内都表现出高效的抗菌特性。此外，在近红外照射下，MBG@Au 的成骨特性也得到了改善。此外，体内研究结果表明，MBG@Au 能有效促进牙槽骨再生，实现严重牙周炎的治愈。

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来源期刊

ACS Biomaterials Science & Engineering Materials Science-Biomaterials

CiteScore

10.30

自引率

3.40%

发文量

413

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