The effect of T cell aging on the change of human tissue structure

IF 5.2 2区医学 Q1 GERIATRICS & GERONTOLOGY Immunity & Ageing Pub Date : 2024-04-30 DOI:10.1186/s12979-024-00433-4

Ling-ling Xu, Xiang Chen, Jing-ping Cheng

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Abstract

The trend of aging of the global population is becoming more and more significant, and the incidence of age-related diseases continues to rise.This phenomenon makes the problem of aging gradually attracted wide attention of the society, and gradually developed into an independent research field.As a vital defense mechanism of the human body, the immune system changes significantly during the aging process.Age-induced changes in the body’s immune system are considered harmful and are commonly referred to as immune aging, which may represent the beginning of systemic aging.Immune cells, especially T cells, are the biggest influencers and participants in age-related deterioration of immune function, making older people more susceptible to different age-related diseases.More and more evidence shows that T cells play an important role in the change of human tissue structure after aging, which fundamentally affects the health and survival of the elderly.In this review, we discuss the general characteristics of age-related T cell immune alterations and the possible effects of aging T cells in various tissue structures in the human body.

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T 细胞老化对人体组织结构变化的影响

全球人口老龄化趋势日益显著，老年性疾病发病率持续上升，这一现象使得老龄化问题逐渐引起社会的广泛关注，并逐渐发展成为一个独立的研究领域。作为人体重要的防御机制，免疫系统在老龄化过程中会发生显著变化，由年龄引起的机体免疫系统变化被认为是有害的，通常被称为免疫衰老，它可能代表着全身衰老的开始。越来越多的证据表明，T 细胞在衰老后人体组织结构的变化中扮演着重要角色，从根本上影响着老年人的健康和生存。在这篇综述中，我们讨论了与年龄相关的 T 细胞免疫改变的一般特征，以及衰老的 T 细胞对人体各种组织结构可能产生的影响。

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来源期刊

Immunity & Ageing GERIATRICS & GERONTOLOGY-IMMUNOLOGY

CiteScore

10.20

自引率

3.80%

发文量

期刊介绍： Immunity & Ageing is a specialist open access journal that was first published in 2004. The journal focuses on the impact of ageing on immune systems, the influence of aged immune systems on organismal well-being and longevity, age-associated diseases with immune etiology, and potential immune interventions to increase health span. All articles published in Immunity & Ageing are indexed in the following databases: Biological Abstracts, BIOSIS, CAS, Citebase, DOAJ, Embase, Google Scholar, Journal Citation Reports/Science Edition, OAIster, PubMed, PubMed Central, Science Citation Index Expanded, SCImago, Scopus, SOCOLAR, and Zetoc.