Psychopathological characteristics in ultra-high risk for psychosis with and without comorbid ADHD

IF 2.1 4区医学 Q3 PSYCHIATRY Early Intervention in Psychiatry Pub Date : 2024-05-01 DOI:10.1111/eip.13539

Michele Ribolsi, Davide Prosperi Porta, Roberto Sacco, Giorgio Di Lorenzo, Federico Fiori Nastro, Giuliano Albergo, Vincenzo Di Lazzaro, Anna Costa

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Abstract

Aim

This study investigates the psychopathological characteristics of a sample of individuals at ultra-high risk for psychosis with and without comorbid attention-deficit hyperactivity disorder (ADHD).

Methods

Twenty-eight subjects (aged 13–21 years; 13 females) with attenuated psychosis syndrome (APS) were recruited in a cross-sectional study and divided into two groups, each with 14 patients, according to the presence or absence of ADHD.

Results

The APS group showed a significantly higher prevalence of negative symptoms than the APS + ADHD group. Other characteristics investigated (positive symptoms, aberrant salience, psychotic-like experiences and prodromal symptoms) did not differ between groups.

Conclusions

The different profiles of negative symptoms in the APS with or without ADHD might suggest the presence of a specific subtype among individuals at ultra-high risk for psychosis. Longitudinal studies with larger samples will provide information about the role of negative symptoms in determining conversion to full psychosis in those people with ‘pure’ APS and those with APS + ADHD.

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伴有或不伴有多动症的超高危精神病患者的精神病理特征

目的：本研究调查了患有或未患有注意力缺陷多动障碍（ADHD）的超高风险精神病患者的精神病理学特征。方法在一项横断面研究中招募了 28 名患有减轻性精神病综合征（APS）的受试者（13 至 21 岁；13 名女性），并根据患者是否患有多动症将其分为两组，每组 14 人。结论患有或不患有多动症的 APS 患者的阴性症状不同，这可能表明在精神病超高风险人群中存在一种特殊的亚型。对更大样本的纵向研究将提供信息，说明阴性症状在决定 "纯 "APS患者和APS+ADHD患者向完全精神病转化过程中的作用。

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来源期刊

Early Intervention in Psychiatry 医学-精神病学

CiteScore

4.80

自引率

5.00%

发文量

112

审稿时长

6-12 weeks

期刊介绍： Early Intervention in Psychiatry publishes original research articles and reviews dealing with the early recognition, diagnosis and treatment across the full range of mental and substance use disorders, as well as the underlying epidemiological, biological, psychological and social mechanisms that influence the onset and early course of these disorders. The journal provides comprehensive coverage of early intervention for the full range of psychiatric disorders and mental health problems, including schizophrenia and other psychoses, mood and anxiety disorders, substance use disorders, eating disorders and personality disorders. Papers in any of the following fields are considered: diagnostic issues, psychopathology, clinical epidemiology, biological mechanisms, treatments and other forms of intervention, clinical trials, health services and economic research and mental health policy. Special features are also published, including hypotheses, controversies and snapshots of innovative service models.