Beyond silence: evolving ultrasound strategies in the battle against cardiovascular thrombotic challenges

IF 2.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Journal of Thrombosis and Thrombolysis Pub Date : 2024-04-30 DOI:10.1007/s11239-024-02989-w

Zhiwen Wang, Nan Jiang, Zhixin Jiang, Qing Deng, Qing Zhou, Bo Hu

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Abstract

Cardiovascular thrombotic events have long been a perplexing factor in clinical settings, influencing patient prognoses significantly. Ultrasound-mediated acoustic therapy, an innovative thrombolytic treatment method known for its high efficiency, non-invasiveness, safety, and convenience, has demonstrated promising potential for clinical applications and has gradually become a focal point in cardiovascular thrombotic disease research. The current challenge lies in the technical complexities of preparing ultrasound-responsive carriers with thrombus-targeting capabilities and high thrombolytic efficiency. Additionally, optimizing the corresponding acoustic treatment mode is crucial to markedly enhance the thrombolytic effectiveness of ultrasound-mediated acoustic therapy. In light of the current status, this article provides a comprehensive review of the research progress in innovative ultrasound-mediated acoustic therapy for cardiovascular thrombotic diseases. It explores the impact of technical methods, therapeutic mechanisms, and influencing factors on the thrombolytic efficiency and clinical potential of ultrasound-mediated acoustic therapy. The review places particular emphasis on identifying solutions and key considerations in addressing the challenges associated with this cutting-edge therapeutic approach.

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超越沉默：应对心血管血栓挑战的超声战略不断发展

长期以来，心血管血栓事件一直是临床上的一个令人困惑的因素，严重影响着患者的预后。超声介导声学疗法作为一种创新的溶栓治疗方法，以其高效、无创、安全、便捷而著称，在临床应用中展现出广阔的前景，并逐渐成为心血管血栓疾病研究的焦点。目前的挑战在于制备具有血栓靶向能力和高溶栓效率的超声响应载体的技术复杂性。此外，优化相应的声学治疗模式对于显著提高超声介导声学疗法的溶栓效果至关重要。鉴于目前的现状，本文全面回顾了创新超声介导声学疗法治疗心血管血栓性疾病的研究进展。文章探讨了超声介导声学疗法的技术方法、治疗机制和影响因素对溶栓效率和临床潜力的影响。综述特别强调了在应对这一前沿治疗方法相关挑战时的解决方案和主要考虑因素。

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来源期刊

Journal of Thrombosis and Thrombolysis 医学-外周血管病

CiteScore

9.20

自引率

0.00%

发文量

112

审稿时长

4-8 weeks

期刊介绍： The Journal of Thrombosis and Thrombolysis is a long-awaited resource for contemporary cardiologists, hematologists, vascular medicine specialists and clinician-scientists actively involved in treatment decisions and clinical investigation of thrombotic disorders involving the cardiovascular and cerebrovascular systems. The principal focus of the Journal centers on the pathobiology of thrombosis and vascular disorders and the use of anticoagulants, platelet antagonists, cell-based therapies and interventions in scientific investigation, clinical-translational research and patient care. The Journal will publish original work which emphasizes the interface between fundamental scientific principles and clinical investigation, stimulating an interdisciplinary and scholarly dialogue in thrombosis and vascular science. Published works will also define platforms for translational research, drug development, clinical trials and patient-directed applications. The Journal of Thrombosis and Thrombolysis'' integrated format will expand the reader''s knowledge base and provide important insights for both the investigation and direct clinical application of the most rapidly growing fields in medicine-thrombosis and vascular science.