The Influence of CD40/CD40L, MMP2/MMP9 on Uterine Artery Blood Flow and Their Expression in Recurrent Miscarriage.

IF 1.9 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Alternative therapies in health and medicine Pub Date : 2025-01-01

Huirong Li, Liang Ding, Jian Ding, Fudan Huang

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Abstract

Objective: This study aims to investigate the expression levels of soluble CD40L (sCD40L), matrix metalloproteinase 2 (MMP2), and matrix metalloproteinase 9 (MMP9) in the serum of patients experiencing recurrent abortion and their impact on uterine artery blood flow.

Methods: A cohort of 200 patients with recurrent abortion was selected for this investigation. The levels of sCD40L, MMP2, and MMP9 in serum were assessed using ELISA, while ultrasound was employed to measure the pulsatility index (PI) and resistance index (RI) in uterine artery blood flow. Pregnancy outcomes were observed, and the expression of CD40/CD40L and MMP2/MMP9 in villi tissues was compared between patients experiencing recurrent abortion failure and those with normal pregnancies.

Results: In the successful pregnancy group of patients with recurrent spontaneous abortion (RSA), serum levels of sCD40L, MMP2, and MMP9 were significantly lower than those in the failed pregnancy group. Additionally, both RI and PI were notably reduced. The expression of each gene showed a correlation with RI and PI. Furthermore, the expression levels of CD40, CD40L, MMP2, and MMP9 in the pregnancy failure group were significantly higher than in the normal voluntary termination group.

Conclusion: Serum levels of sCD40L, MMP2, and MMP9, along with non-invasive and easily accessible indicators such as PI and RI in uterine artery blood flow measured by ultrasound, emerge as potential predictive markers for the outcome of recurrent miscarriage pregnancies. Moreover, these indicators can serve as valuable evaluation markers in clinical practice, facilitating the monitoring of treatment effectiveness for recurrent miscarriage.

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CD40/CD40L、MMP2/MMP9对子宫动脉血流的影响及其在复发性流产中的表达

研究目的本研究旨在探讨复发性流产患者血清中可溶性CD40L（sCD40L）、基质金属蛋白酶2（MMP2）和基质金属蛋白酶9（MMP9）的表达水平及其对子宫动脉血流的影响：方法：本研究选取了 200 例复发性流产患者作为研究对象。方法：该研究选取了 200 例复发性流产患者，采用 ELISA 方法评估血清中 sCD40L、MMP2 和 MMP9 的水平，并采用超声波测量子宫动脉血流的脉动指数（PI）和阻力指数（RI）。观察妊娠结局，并比较复发性流产失败患者和正常妊娠患者绒毛组织中 CD40/CD40L 和 MMP2/MMP9 的表达情况：结果：在复发性自然流产（RSA）患者的成功妊娠组中，血清中的sCD40L、MMP2和MMP9水平明显低于失败妊娠组。此外，RI 和 PI 也明显降低。各基因的表达均与 RI 和 PI 相关。此外，妊娠失败组的 CD40、CD40L、MMP2 和 MMP9 的表达水平明显高于正常自愿终止妊娠组：结论：血清中的 sCD40L、MMP2 和 MMP9 水平，以及超声波测量的子宫动脉血流中的 PI 和 RI 等非侵入性且容易获得的指标，是复发性流产妊娠结局的潜在预测指标。此外，这些指标在临床实践中可作为有价值的评估指标，有助于监测复发性流产的治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alternative therapies in health and medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

0.90

自引率

0.00%

发文量

219

期刊介绍： Launched in 1995, Alternative Therapies in Health and Medicine has a mission to promote the art and science of integrative medicine and a responsibility to improve public health. We strive to maintain the highest standards of ethical medical journalism independent of special interests that is timely, accurate, and a pleasure to read. We publish original, peer-reviewed scientific articles that provide health care providers with continuing education to promote health, prevent illness, and treat disease. Alternative Therapies in Health and Medicine was the first journal in this field to be indexed in the National Library of Medicine. In 2006, 2007, and 2008, ATHM had the highest impact factor ranking of any independently published peer-reviewed CAM journal in the United States—meaning that its research articles were cited more frequently than any other journal’s in the field. Alternative Therapies in Health and Medicine does not endorse any particular system or method but promotes the evaluation and appropriate use of all effective therapeutic approaches. Each issue contains a variety of disciplined inquiry methods, from case reports to original scientific research to systematic reviews. The editors encourage the integration of evidence-based emerging therapies with conventional medical practices by licensed health care providers in a way that promotes a comprehensive approach to health care that is focused on wellness, prevention, and healing. Alternative Therapies in Health and Medicine hopes to inform all licensed health care practitioners about developments in fields other than their own and to foster an ongoing debate about the scientific, clinical, historical, legal, political, and cultural issues that affect all of health care.