Effect of water temperature on the anesthetic effects of alfaxalone in carp (Cyprinus carpio).

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-03-12 eCollection Date: 2024-03-01 DOI:10.5455/javar.2024.k743

Kenichi Maeda, Daiki Hotta, Takuma Matsui, Satomi Iwai, Shozo Okanao

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Abstract

Objective: To evaluate the effect of water temperature on intramuscular injected alfaxalone anesthesia in carp (Cyprinus carpio).

Materials and methods: Six healthy adult carp (C. carpio) were intramuscularly injected with alfaxalone (2.5, 5.0, or 7.5 mg/kg) at normal water temperature (25°C) and at low water temperature (2.5 mg/kg, 15°C). The respiratory rate, heart rate (HR), and anesthesia depth (AD) were evaluated every 5 min for 30 min after administration and every 1 h after 60 min after injection.

Results: The respiratory and HRs did not change significantly upon alfaxalone injection, regardless of dose. However, a dose-dependent increase in AD scores was observed. Furthermore, 2.5 mg/kg alfaxalone injected in 15°C water showed an almost equal anesthetic effect to that of 5.0 mg/kg alfaxalone in 25°C water.

Conclusion: Alfaxalone is readily available, and its anesthetic effect in carp was enhanced by lowering water temperature, illustrating the possibility of intramuscular injection of alfaxalone in fish.

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水温对阿法沙酮在鲤鱼体内麻醉效果的影响。

目的：评估水温对鲤鱼肌肉注射阿法沙酮麻醉的影响：评估水温对鲤鱼肌肉注射阿法沙酮麻醉的影响：在正常水温（25°C）和低水温（2.5 毫克/千克，15°C）下，给 6 条健康成年鲤鱼肌肉注射阿法沙酮（2.5、5.0 或 7.5 毫克/千克）。给药后 30 分钟内每隔 5 分钟评估一次呼吸频率、心率和麻醉深度，注射后 60 分钟后每隔 1 小时评估一次麻醉深度：结果：注射阿法沙酮后，无论剂量大小，呼吸频率和心率均无明显变化。然而，AD评分的增加与剂量有关。此外，在15°C水中注射2.5毫克/千克阿法沙酮与在25°C水中注射5.0毫克/千克阿法沙酮的麻醉效果几乎相同：结论：阿法沙隆很容易获得，降低水温可增强其对鲤鱼的麻醉效果，这说明了在鱼类肌肉注射阿法沙隆的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.