Green synthesized silver nanoparticles of Terminalia bellirica leaves extract: synthesis, characterization, in-silico studies, and antimalarial activity.

IF 4.5 3区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2024-12-01 Epub Date: 2024-05-02 DOI:10.1080/21691401.2024.2339429
Sujeet Singh, Hemant Arya, Welka Sahu, K Sony Reddy, Surendra Nimesh, Bader Saud Alotaibi, Mohammed Ageeli Hakami, Hassan H Almasoudi, Khater Balatone Gezira Hessien, Mohammad Raghibul Hasan, Summya Rashid, Tarun Kumar Bhatt
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Abstract

Malaria is a mosquito-borne infectious disease that is caused by the Plasmodium parasite. Most of the available medication are losing their efficacy. Therefore, it is crucial to create fresh leads to combat malaria. Green silver nanoparticles (AgNPs) have recently attracted a lot of attention in biomedical research. As a result, green mediated AgNPs from leaves of Terminalia bellirica, a medicinal plant with purported antimalarial effects, were used in this investigation. Initially, cysteine-rich proteins from Plasmodium species were studied in silico as potential therapeutic targets. With docking scores between -9.93 and -11.25 kcal/mol, four leaf constituents of Terminalia bellirica were identified. The green mediated silver nanoparticles were afterward produced using leaf extract and were further examined using UV-vis spectrophotometer, DLS, Zeta potential, FTIR, XRD, and FESEM. The size of synthesized TBL-AgNPs was validated by the FESEM results; the average size of TBL-AgNPs was around 44.05 nm. The zeta potential study also supported green mediated AgNPs stability. Additionally, Plasmodium falciparum (3D7) cultures were used to assess the antimalarial efficacy, and green mediated AgNPs could effectively inhibit the parasitized red blood cells (pRBCs). In conclusion, this novel class of AgNPs may be used as a potential therapeutic replacement for the treatment of malaria.

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槟榔叶提取物的绿色合成银纳米粒子:合成、表征、硅内研究和抗疟活性。
疟疾是一种由疟原虫引起的蚊媒传染病。现有的大多数药物都失去了疗效。因此,开发新的抗疟疾药物至关重要。最近,绿色银纳米粒子(AgNPs)在生物医学研究领域引起了广泛关注。因此,本研究采用了一种据称具有抗疟作用的药用植物 Terminalia bellirica 叶子中的绿色介导 AgNPs。最初,研究人员将疟原虫物种中富含半胱氨酸的蛋白质作为潜在的治疗目标进行了硅学研究。根据-9.93和-11.25 kcal/mol之间的对接得分,确定了四种Terminalia bellirica的叶片成分。随后,利用叶提取物制备了绿色介导的银纳米粒子,并使用紫外-可见分光光度计、DLS、Zeta 电位、傅立叶变换红外光谱、XRD 和 FESEM 对其进行了进一步检测。FESEM 结果验证了合成的 TBL-AgNPs 的尺寸;TBL-AgNPs 的平均尺寸约为 44.05 nm。zeta 电位研究也证明了绿色介导的 AgNPs 的稳定性。此外,用恶性疟原虫(3D7)培养物来评估抗疟药效,绿色介导的 AgNPs 能有效抑制寄生红细胞(pRBCs)。总之,这种新型的 AgNPs 可用作治疗疟疾的潜在替代疗法。
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来源期刊
Artificial Cells, Nanomedicine, and Biotechnology
Artificial Cells, Nanomedicine, and Biotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-ENGINEERING, BIOMEDICAL
CiteScore
10.90
自引率
0.00%
发文量
48
审稿时长
20 weeks
期刊介绍: Artificial Cells, Nanomedicine and Biotechnology covers the frontiers of interdisciplinary research and application, combining artificial cells, nanotechnology, nanobiotechnology, biotechnology, molecular biology, bioencapsulation, novel carriers, stem cells and tissue engineering. Emphasis is on basic research, applied research, and clinical and industrial applications of the following topics:artificial cellsblood substitutes and oxygen therapeuticsnanotechnology, nanobiotecnology, nanomedicinetissue engineeringstem cellsbioencapsulationmicroencapsulation and nanoencapsulationmicroparticles and nanoparticlesliposomescell therapy and gene therapyenzyme therapydrug delivery systemsbiodegradable and biocompatible polymers for scaffolds and carriersbiosensorsimmobilized enzymes and their usesother biotechnological and nanobiotechnological approachesRapid progress in modern research cannot be carried out in isolation and is based on the combined use of the different novel approaches. The interdisciplinary research involving novel approaches, as discussed above, has revolutionized this field resulting in rapid developments. This journal serves to bring these different, modern and futuristic approaches together for the academic, clinical and industrial communities to allow for even greater developments of this highly interdisciplinary area.
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