Time to Treatment Failure and Its Predictors Among Second-Line ART Clients in Amhara Region, Ethiopia: A Retrospective Follow-Up Study.

IF 1.5 Q4 INFECTIOUS DISEASES HIV AIDS-Research and Palliative Care Pub Date : 2024-05-02 eCollection Date: 2024-01-01 DOI:10.2147/HIV.S455885
Habtamu Wagnew Abuhay, Tizazu Endalew, Tilahun Yemanu Birhan, Achenef Asmamaw Muche
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Abstract

Background: Second-line antiretroviral treatment failure has become a major public health issue, and the time to treatment failure among second-line ART clients varies globally, and the Sub-Saharan African region having a high rate of second-line ART treatment failures. In addition, after the ART treatment guideline changed there is limited information on Ethiopia. Therefore, this study aimed to assess time to treatment failure and its determinants among second-line ART clients in Amhara Region, Ethiopia.

Methods: A multi-centered retrospective follow-up study was conducted. A random sample of 860 people on second-line ART was selected by using a computer-generated simple random sampling technique from January 30, 2016, to January 30, 2021, at the University of Gondar Compressive Specialized Hospital, Felege Hiwot Compressive Specialized Referral Hospital, and Debre Tabor Compressive Specialized Referral Hospital, in Amhara region, Ethiopia. Data was captured using a checklist.

Results: A total of 81 (9.4%) ART clients developed second-line treatment failure, with a median follow-up time of 29 months with an interquartile range (IQR: 18, 41]. The risk of second-line treatment failure is higher among patients aged 15 to 30 years (adjusted hazard ratio (AHR) = 2.01, 95% confidence interval (CI): [1.16, 3.48]). Being unable to read and write (AHR = 1.312, 95% CI: [1.068, 1.613]), and poor ART drug adherence (AHR = 3.067, 95% CI: [1.845, 5.099]) were significant predictors of second-line ART treatment failures.

Conclusion: In the current study, the time to second-line ART treatment failure was high compared with a previous similar study in Ethiopia. Factors like being younger age, ART clients who are not being able to read and write, and having poor ART drug adherence was significant predictors of second-line ART treatment failure.

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埃塞俄比亚阿姆哈拉地区二线抗逆转录病毒疗法患者治疗失败的时间及其预测因素:回顾性随访研究。
背景:二线抗逆转录病毒疗法治疗失败已成为一个重大的公共卫生问题,全球二线抗逆转录病毒疗法患者治疗失败的时间各不相同,撒哈拉以南非洲地区的二线抗逆转录病毒疗法治疗失败率较高。此外,在抗逆转录病毒疗法治疗指南变更后,有关埃塞俄比亚的信息非常有限。因此,本研究旨在评估埃塞俄比亚阿姆哈拉地区二线抗逆转录病毒疗法患者治疗失败的时间及其决定因素:方法:开展了一项多中心回顾性随访研究。从 2016 年 1 月 30 日至 2021 年 1 月 30 日,在埃塞俄比亚阿姆哈拉地区的贡达尔大学压缩专科医院、Felege Hiwot 压缩专科转诊医院和 Debre Tabor 压缩专科转诊医院,使用计算机生成的简单随机抽样技术随机抽取了 860 名二线抗逆转录病毒疗法患者。数据采用核对表采集:共有 81 名(9.4%)抗逆转录病毒疗法患者出现二线治疗失败,随访时间中位数为 29 个月,四分位数间距(IQR:18-41])。15-30 岁的患者二线治疗失败的风险更高(调整后危险比 (AHR) = 2.01,95% 置信区间 (CI):[1.16, 3.48])。不识字(AHR = 1.312,95% CI:[1.068, 1.613])和抗逆转录病毒疗法药物依从性差(AHR = 3.067,95% CI:[1.845, 5.099])是二线抗逆转录病毒疗法治疗失败的重要预测因素:结论:与之前在埃塞俄比亚进行的类似研究相比,本次研究中抗逆转录病毒疗法二线治疗失败的时间较长。年龄较小、抗逆转录病毒疗法患者不识字、抗逆转录病毒疗法药物依从性差等因素是二线抗逆转录病毒疗法治疗失败的重要预测因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.00
自引率
6.70%
发文量
61
审稿时长
16 weeks
期刊介绍: About Dove Medical Press Dove Medical Press Ltd is part of Taylor & Francis Group, the Academic Publishing Division of Informa PLC. We specialize in the publication of Open Access peer-reviewed journals across the broad spectrum of science, technology and especially medicine. Dove Medical Press was founded in 2003 with the objective of combining the highest editorial standards with the ''best of breed'' new publishing technologies. We have offices in Manchester and London in the United Kingdom, representatives in Princeton, New Jersey in the United States, and our editorial offices are in Auckland, New Zealand. Dr Scott Fraser is our Medical Director based in the UK. He has been in full time clinical practice for over 20 years as well as having an active research interest.
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