Establishing biomarkers for soft tissue sarcomas.

IF 2.9 3区医学 Q2 ONCOLOGY Expert Review of Anticancer Therapy Pub Date : 2024-06-01 Epub Date: 2024-04-30 DOI:10.1080/14737140.2024.2346187

Anna M Czarnecka, Paulina Chmiel, Piotr Błoński, Piotr Rutkowski

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Abstract

Introduction: Soft tissue sarcomas (STS) are a rare and diverse group of tumors. Curative options are limited to localized disease, with surgery being the mainstay. Advanced stages are associated with a poor prognosis. Currently, the prognosis of the patient is based on histological classification and clinical characteristics, with only a few biomarkers having entered clinical practice.

Areas covered: This article covers extensive recent research that has established novel potential biomarkers based on genomics, proteomics, and clinical characteristics. Validating and incorporating these biomarkers into clinical practice can improve prognosis, prediction of recurrence, and treatment response. Relevant literature was collected from PubMed, Scopus, and clinicaltrials.gov databases (November 2023).

Expert opinion: Currently, defining prognostic markers in soft tissue sarcomas remains challenging. More studies are required, especially to personalize treatment through advanced genetic profiling and analysis using individual tumor and patient characteristics.

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建立软组织肉瘤的生物标记。

简介软组织肉瘤（STS）是一种罕见的多种肿瘤。治疗方法仅限于局部疾病，手术是主要手段。晚期患者预后较差。目前，对患者预后的判断主要基于组织学分类和临床特征，只有少数生物标志物已进入临床实践：本文介绍了近期开展的大量研究，这些研究基于基因组学、蛋白质组学和临床特征建立了新的潜在生物标志物。验证这些生物标志物并将其纳入临床实践可改善预后、预测复发和治疗反应。相关文献来自 PubMed、Scopus 和 clinicaltrials.gov 数据库（2023 年 11 月）：目前，确定软组织肉瘤的预后标志物仍具有挑战性。需要进行更多的研究，尤其是通过先进的基因谱分析和利用肿瘤及患者个体特征进行分析，实现个性化治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Anticancer Therapy 医学-肿瘤学

CiteScore

5.10

自引率

3.00%

发文量

100

审稿时长

4-8 weeks

期刊介绍： Expert Review of Anticancer Therapy (ISSN 1473-7140) provides expert appraisal and commentary on the major trends in cancer care and highlights the performance of new therapeutic and diagnostic approaches. Coverage includes tumor management, novel medicines, anticancer agents and chemotherapy, biological therapy, cancer vaccines, therapeutic indications, biomarkers and diagnostics, and treatment guidelines. All articles are subject to rigorous peer-review, and the journal makes an essential contribution to decision-making in cancer care. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points.