Cardiorenal Impact of Anti-Cancer Agents: The Intersection of Onco-Nephrology and Cardio-Oncology.

IF 2.4 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Cardiorenal Medicine Pub Date : 2024-01-01 Epub Date: 2024-04-29 DOI:10.1159/000539075

Rose Mary Attieh, Belen Nunez, Robert S Copeland-Halperin, Kenar D Jhaveri

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Abstract

Background: The evolving landscape of cancer treatments has introduced new challenges, particularly related to adverse events associated with chemotherapeutic agents. To address these challenges, the fields of cardio-oncology and onco-nephrology have arisen, focusing on the management of cardiotoxicity and nephrotoxicity attributable to anti-cancer drugs.

Summary: Numerous intersections between these disciplines exist, including onco-hypertension (HTN) and cardiorenal toxicities induced by chemotherapeutic agents. Additionally, immune checkpoint inhibitors (ICIs) may cause myocarditis and nephritis. This paper aimed to explore the intersection between cardio-oncology and onco-nephrology. A detailed review will be undertaken, focusing on onco-HTN and the cardiorenal toxicities of chemotherapeutic agents, with a specific emphasis on the adverse effects associated with ICIs.

Key messages: Multidisciplinary collaboration among oncologists, cardiologists, nephrologists, and other healthcare professionals is crucial for developing tailored approaches to optimize treatment efficacy while minimizing the risk of cardiovascular and renal complications, ultimately enhancing patient outcomes in modern oncology practice.

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抗癌药物对心肾功能的影响：肿瘤肾脏病学与心脏肿瘤学的交汇点。

癌症治疗领域的不断发展带来了新的挑战，尤其是与化疗药物相关的不良反应。为了应对这些挑战，心肿瘤学和肿瘤肾脏病学领域应运而生，重点研究抗癌药物引起的心脏毒性和肾毒性。这些学科之间存在许多交叉点，包括化疗药物诱发的肿瘤高血压和心肾毒性。此外，免疫检查点抑制剂可能导致心肌炎和肾炎。肿瘤学家、心脏病学家、肾脏病学家和其他医疗保健专业人士之间的多学科合作对于制定量身定制的方法至关重要，以便在优化治疗效果的同时最大限度地降低心血管和肾脏并发症的风险，最终提高现代肿瘤学实践中患者的治疗效果。

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来源期刊

Cardiorenal Medicine CARDIAC & CARDIOVASCULAR SYSTEMS-UROLOGY & NEPHROLOGY

CiteScore

5.40

自引率

2.60%

发文量

审稿时长

>12 weeks

期刊介绍： The journal ''Cardiorenal Medicine'' explores the mechanisms by which obesity and other metabolic abnormalities promote the pathogenesis and progression of heart and kidney disease (cardiorenal metabolic syndrome). It provides an interdisciplinary platform for the advancement of research and clinical practice, focussing on translational issues.