Family history and gastric cancer incidence and mortality in Asia: a pooled analysis of more than half a million participants.

IF 6 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Gastric Cancer Pub Date : 2024-07-01 Epub Date: 2024-04-22 DOI:10.1007/s10120-024-01499-1

Dan Huang, Minkyo Song, Sarah Krull Abe, Md Shafiur Rahman, Md Rashedul Islam, Eiko Saito, Katherine De la Torre, Norie Sawada, Akiko Tamakoshi, Xiao-Ou Shu, Hui Cai, Atsushi Hozawa, Seiki Kanemura, Jeongseon Kim, Yu Chen, Hidemi Ito, Yumi Sugawara, Sue K Park, Myung-Hee Shin, Mayo Hirabayashi, Takashi Kimura, Yu-Tang Gao, Wanqing Wen, Isao Oze, Aesun Shin, Yoon-Ok Ahn, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang

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Abstract

Background: The family history of gastric cancer holds important implications for cancer surveillance and prevention, yet existing evidence predominantly comes from case-control studies. We aimed to investigate the association between family history of gastric cancer and gastric cancer risk overall and by various subtypes in Asians in a prospective study.

Methods: We included 12 prospective cohorts with 550,508 participants in the Asia Cohort Consortium. Cox proportional hazard regression was used to estimate study-specific adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between family history of gastric cancer and gastric cancer incidence and mortality, then pooled using random-effects meta-analyses. Stratified analyses were performed for the anatomical subsites and histological subtypes.

Results: During the mean follow-up of 15.6 years, 2258 incident gastric cancers and 5194 gastric cancer deaths occurred. The risk of incident gastric cancer was higher in individuals with a family history of gastric cancer (HR 1.44, 95% CI 1.32-1.58), similarly in males (1.44, 1.31-1.59) and females (1.45, 1.23-1.70). Family history of gastric cancer was associated with both cardia (HR 1.26, 95% CI 1.00-1.60) and non-cardia subsites (1.49, 1.35-1.65), and with intestinal- (1.48, 1.30-1.70) and diffuse-type (1.59, 1.35-1.87) gastric cancer incidence. Positive associations were also found for gastric cancer mortality (HR 1.30, 95% CI 1.19-1.41).

Conclusions: In this largest prospective study to date on family history and gastric cancer, a familial background of gastric cancer increased the risk of gastric cancer in the Asian population. Targeted education, screening, and intervention in these high-risk groups may reduce the burden of gastric cancer.

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亚洲的家族史与胃癌发病率和死亡率：对 50 多万参与者的汇总分析。

背景：胃癌家族史对癌症监测和预防具有重要意义，但现有证据主要来自病例对照研究。我们旨在通过一项前瞻性研究，调查胃癌家族史与亚洲人胃癌总体风险及不同亚型胃癌风险之间的关联：方法：我们纳入了亚洲队列联合会（Asia Cohort Consortium）的 12 个前瞻性队列，共有 550,508 名参与者。我们采用 Cox 比例危险回归法估算了胃癌家族史与胃癌发病率和死亡率之间关系的特异性调整后危险比 (HRs) 和 95% 置信区间 (CIs)，然后采用随机效应荟萃分析进行了汇总。对解剖亚部位和组织学亚型进行了分层分析：结果：在平均 15.6 年的随访期间，共发生 2258 例胃癌和 5194 例胃癌死亡。有胃癌家族史的人罹患胃癌的风险更高（HR 1.44，95% CI 1.32-1.58），男性（1.44，1.31-1.59）和女性（1.45，1.23-1.70）的情况类似。胃癌家族史与贲门（HR 1.26，95% CI 1.00-1.60）和非贲门亚部位（1.49，1.35-1.65）以及肠型（1.48，1.30-1.70）和弥漫型（1.59，1.35-1.87）胃癌的发病率相关。胃癌死亡率也呈正相关（HR 1.30，95% CI 1.19-1.41）：在这项迄今为止最大规模的关于家族史与胃癌的前瞻性研究中，有胃癌家族背景的亚洲人患胃癌的风险更高。对这些高危人群进行有针对性的教育、筛查和干预可能会减轻胃癌的负担。

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来源期刊

Gastric Cancer 医学-胃肠肝病学

CiteScore

14.70

自引率

2.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Gastric Cancer is an esteemed global forum that focuses on various aspects of gastric cancer research, treatment, and biology worldwide. The journal promotes a diverse range of content, including original articles, case reports, short communications, and technical notes. It also welcomes Letters to the Editor discussing published articles or sharing viewpoints on gastric cancer topics. Review articles are predominantly sought after by the Editor, ensuring comprehensive coverage of the field. With a dedicated and knowledgeable editorial team, the journal is committed to providing exceptional support and ensuring high levels of author satisfaction. In fact, over 90% of published authors have expressed their intent to publish again in our esteemed journal.