Association between tonsillectomy and risk of oropharyngeal cancer: a systematic review.

IF 2.1 4区医学 Q2 OTORHINOLARYNGOLOGY Acta Otorhinolaryngologica Italica Pub Date : 2024-06-01 Epub Date: 2024-05-03 DOI:10.14639/0392-100X-N2790

Chengxiang Bai, Mingfen He, Shuang Li, Jing Liu, Linxiu Zhong, Feng Chen, Lanying Zhou, Yanfeng Jiang

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Abstract

Objective: Studies have demonstrated that tonsillectomy may alter the risk of oropharyngeal cancer (OPC). We systematically reviewed the evidence and pooled data to examine such an association.

Methods: PubMed, Embase, and Scopus were searched up to 25^th April 2023. Studies reporting an association between tonsillectomy and oropharyngeal cancer risk at any site were included.

Results: Five studies were eligible. All examined the risk of tonsillar and base of the tongue (BOT) cancer with prior history of tonsillectomy. On meta-analysis of the data, prior history of tonsillectomy was associated with a significantly decreased risk of tonsillar cancer. The second meta-analysis showed that history of tonsillectomy did not significantly alter the risk of BOT cancer. However, after exclusion of one study, the results showed an increased risk of BOT cancer with a history of tonsillectomy.

Conclusions: The scarce data available in the literature suggests that tonsillectomy may reduce the risk of tonsillar cancer but does not alter the risk of BOT cancer. Further studies are needed to explore the association between tonsillectomy and the risk of OPC.

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扁桃体切除术与口咽癌风险之间的关系：系统综述。

目的：研究表明，扁桃体切除术可能会改变口咽癌（OPC）的发病风险。我们系统地回顾了相关证据并汇总了数据，以研究这种关联：方法：检索了截至 2023 年 4 月 25 日的 PubMed、Embase 和 Scopus。结果：有五项研究符合条件：结果：五项研究符合条件。所有研究都探讨了扁桃体和舌根 (BOT) 癌症风险与扁桃体切除术前病史的关系。对数据进行荟萃分析后发现，扁桃体切除术前病史与扁桃体癌风险的显著降低有关。第二项荟萃分析表明，扁桃体切除术史并不会显著改变罹患 BOT 癌症的风险。然而，在排除一项研究后，结果显示扁桃体切除术史会增加罹患 BOT 癌的风险：文献中的稀缺数据表明，扁桃体切除术可降低扁桃体癌的风险，但不会改变 BOT 癌的风险。需要进一步研究扁桃体切除术与 OPC 风险之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Otorhinolaryngologica Italica OTORHINOLARYNGOLOGY-

CiteScore

3.40

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Acta Otorhinolaryngologica Italica first appeared as “Annali di Laringologia Otologia e Faringologia” and was founded in 1901 by Giulio Masini. It is the official publication of the Italian Hospital Otology Association (A.O.O.I.) and, since 1976, also of the Società Italiana di Otorinolaringoiatria e Chirurgia Cervico-Facciale (S.I.O.Ch.C.-F.). The journal publishes original articles (clinical trials, cohort studies, case-control studies, cross-sectional surveys, and diagnostic test assessments) of interest in the field of otorhinolaryngology as well as clinical techniques and technology (a short report of unique or original methods for surgical techniques, medical management or new devices or technology), editorials (including editorial guests – special contribution) and letters to the Editor-in-Chief. Articles concerning science investigations and well prepared systematic reviews (including meta-analyses) on themes related to basic science, clinical otorhinolaryngology and head and neck surgery have high priority.