Associations Between Beverage Consumption and Risk of Microvascular Complications Among Individuals With Type 2 Diabetes.

IF 5 2区医学 Q1 ENDOCRINOLOGY & METABOLISM Journal of Clinical Endocrinology & Metabolism Pub Date : 2025-02-18 DOI:10.1210/clinem/dgae242

Xiaoyu Lin, Kai Zhu, Zixin Qiu, Rui Li, Lin Li, Qi Lu, Ruyi Li, Hancheng Yu, Sen Liu, Tianyu Guo, Kun Yang, Yunfei Liao, An Pan, Gang Liu

{"title":"Associations Between Beverage Consumption and Risk of Microvascular Complications Among Individuals With Type 2 Diabetes.","authors":"Xiaoyu Lin, Kai Zhu, Zixin Qiu, Rui Li, Lin Li, Qi Lu, Ruyi Li, Hancheng Yu, Sen Liu, Tianyu Guo, Kun Yang, Yunfei Liao, An Pan, Gang Liu","doi":"10.1210/clinem/dgae242","DOIUrl":null,"url":null,"abstract":"Context: The relationship between the consumption of different beverages and the risk of microvascular complications in individuals with type 2 diabetes (T2D) is unclear.Objective: To investigate the association of individual beverage consumption, including artificially sweetened beverages (ASBs), sugar-sweetened beverages (SSBs), tea, coffee, natural juice, and yogurt, with the risk of microvascular complications in adults with T2D.Methods: This cohort study included 6676 participants with T2D who were free of macrovascular and microvascular complications at baseline in the UK Biobank. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs).Results: During a median follow-up of 11.7 years, 1116 cases of composite microvascular complications were documented. After multivariable adjustment, a linear dose-response relationship was demonstrated between the consumption of ASBs and SSBs and the risk of microvascular complications. Compared with nonconsumers, those who consumed ≥2.0 units/day of ASBs and SSBs had an HR (95% CI) of 1.44 (1.18-1.75) and 1.32 (1.00-1.76) for composite microvascular complications, respectively. In addition, higher tea consumption was associated with a lower risk of diabetic retinopathy, with an HR (95% CI) of 0.72 (0.57-0.92) for whom consuming ≥4.0 units/day. There was no significant association between individual beverage consumption and the risk of diabetic neuropathy. No significant association was observed between the consumption of coffee, natural juice, or yogurt and the risks of microvascular complications. Moreover, substituting half units/day of ASBs or SSBs with tea or coffee was associated with a 16% to 28% lower risk of microvascular complications.Conclusion: Higher consumption of ASBs and SSBs was linearly associated with an increased risk of microvascular complications in adults with T2D.","PeriodicalId":50238,"journal":{"name":"Journal of Clinical Endocrinology & Metabolism","volume":" ","pages":"e802-e813"},"PeriodicalIF":5.0000,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Endocrinology & Metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1210/clinem/dgae242","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Context: The relationship between the consumption of different beverages and the risk of microvascular complications in individuals with type 2 diabetes (T2D) is unclear.

Objective: To investigate the association of individual beverage consumption, including artificially sweetened beverages (ASBs), sugar-sweetened beverages (SSBs), tea, coffee, natural juice, and yogurt, with the risk of microvascular complications in adults with T2D.

Methods: This cohort study included 6676 participants with T2D who were free of macrovascular and microvascular complications at baseline in the UK Biobank. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs).

Results: During a median follow-up of 11.7 years, 1116 cases of composite microvascular complications were documented. After multivariable adjustment, a linear dose-response relationship was demonstrated between the consumption of ASBs and SSBs and the risk of microvascular complications. Compared with nonconsumers, those who consumed ≥2.0 units/day of ASBs and SSBs had an HR (95% CI) of 1.44 (1.18-1.75) and 1.32 (1.00-1.76) for composite microvascular complications, respectively. In addition, higher tea consumption was associated with a lower risk of diabetic retinopathy, with an HR (95% CI) of 0.72 (0.57-0.92) for whom consuming ≥4.0 units/day. There was no significant association between individual beverage consumption and the risk of diabetic neuropathy. No significant association was observed between the consumption of coffee, natural juice, or yogurt and the risks of microvascular complications. Moreover, substituting half units/day of ASBs or SSBs with tea or coffee was associated with a 16% to 28% lower risk of microvascular complications.

Conclusion: Higher consumption of ASBs and SSBs was linearly associated with an increased risk of microvascular complications in adults with T2D.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

2 型糖尿病患者饮用饮料与微血管并发症风险之间的关系。

背景：2型糖尿病（T2D）患者饮用不同饮料与微血管并发症风险之间的关系尚不明确：目的：研究2型糖尿病成人微血管并发症风险与单种饮料（包括人工甜饮料、含糖饮料、茶、咖啡、天然果汁和酸奶）摄入量的关系：这项队列研究纳入了英国生物库中基线无大血管和微血管并发症的 6676 名 T2D 患者。研究采用 Cox 比例危险模型计算危险比 (HR) 和 95% 置信区间 (CI)：结果：在中位 11.7 年的随访期间，共记录了 1116 例复合微血管并发症。经多变量调整后，ASBs 和 SSBs 消费量与微血管并发症风险之间呈线性剂量反应关系。与不消费的人相比，每天消费≥2.0单位的ASB和SSB的人发生微血管综合并发症的HR（95% CI）分别为1.44（1.18-1.75）和1.32（1.00-1.76）。此外，饮茶量越高，糖尿病视网膜病变的风险越低，饮茶量≥4.0单位/天的HR（95% CI）为0.72（0.57-0.92）。个别饮料的摄入量与糖尿病神经病变的风险之间没有明显关联。饮用咖啡、天然果汁或酸奶与微血管并发症的风险之间没有明显的关联。此外，用茶或咖啡代替每天半单位的ASB或SSB，微血管并发症的风险会降低16%至28%：结论：ASB 和 SSB 消费量的增加与患有 T2D 的成年人微血管并发症风险的增加呈线性关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Journal of Clinical Endocrinology & Metabolism 医学-内分泌学与代谢

CiteScore

11.40

自引率

5.20%

发文量

673

审稿时长

1 months

期刊介绍： The Journal of Clinical Endocrinology & Metabolism is the world"s leading peer-reviewed journal for endocrine clinical research and cutting edge clinical practice reviews. Each issue provides the latest in-depth coverage of new developments enhancing our understanding, diagnosis and treatment of endocrine and metabolic disorders. Regular features of special interest to endocrine consultants include clinical trials, clinical reviews, clinical practice guidelines, case seminars, and controversies in clinical endocrinology, as well as original reports of the most important advances in patient-oriented endocrine and metabolic research. According to the latest Thomson Reuters Journal Citation Report, JCE&M articles were cited 64,185 times in 2008.