Strategies to reprogram anti-inflammatory macrophages towards pro-inflammatory macrophages to support cancer immunotherapies

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-05-03 DOI:10.1016/j.imlet.2024.106864
Ana Vizcaino Castro, Toos Daemen, Cesar Oyarce
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Abstract

Tumor-associated myeloid cells, including macrophages and myeloid-derived suppressor cells, can be highly prevalent in solid tumors and play a significant role in the development of the tumor. Therefore, myeloid cells are being considered potential targets for cancer immunotherapies. In this review, we focused on strategies aimed at targeting tumor-associated macrophages (TAMs). Most strategies were studied preclinically but we also included a limited number of clinical studies based on these strategies. We describe possible underlying mechanisms and discuss future challenges and prospects.

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将抗炎巨噬细胞重编程为促炎巨噬细胞以支持癌症免疫疗法的策略。
包括巨噬细胞和髓源性抑制细胞在内的肿瘤相关髓系细胞在实体瘤中非常普遍,并在肿瘤的发展过程中扮演着重要角色。因此,髓系细胞被认为是癌症免疫疗法的潜在靶点。在这篇综述中,我们重点讨论了针对肿瘤相关巨噬细胞(TAMs)的策略。大多数策略都是临床前研究,但我们也纳入了基于这些策略的少量临床研究。我们描述了可能的内在机制,并讨论了未来的挑战和前景。
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CiteScore
7.20
自引率
4.30%
发文量
567
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