Microscale marvels: unveiling the macroscopic significance of micropeptides in human health.

IF 2.5 3区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Briefings in Functional Genomics Pub Date : 2024-09-27 DOI:10.1093/bfgp/elae018

Deepyaman Das, Soumita Podder

引用次数: 0

Abstract

Non-coding RNA encodes micropeptides from small open reading frames located within the RNA. Interestingly, these micropeptides are involved in a variety of functions within the body. They are emerging as the resolving piece of the puzzle for complex biomolecular signaling pathways within the body. Recent studies highlight the pivotal role of small peptides in regulating important biological processes like DNA repair, gene expression, muscle regeneration, immune responses, etc. On the contrary, altered expression of micropeptides also plays a pivotal role in the progression of various diseases like cardiovascular diseases, neurological disorders and several types of cancer, including colorectal cancer, hepatocellular cancer, lung cancer, etc. This review delves into the dual impact of micropeptides on health and pathology, exploring their pivotal role in preserving normal physiological homeostasis and probing their involvement in the triggering and progression of diseases.

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微观奇迹：揭示微肽对人类健康的宏观意义。

非编码 RNA 通过位于 RNA 中的小型开放阅读框编码微肽。有趣的是，这些微肽参与了人体内的各种功能。它们正在成为体内复杂生物分子信号通路的拼图。最近的研究强调了小肽在调节 DNA 修复、基因表达、肌肉再生、免疫反应等重要生物过程中的关键作用。相反，微肽表达的改变也在心血管疾病、神经系统疾病和几种癌症（包括结肠直肠癌、肝癌、肺癌等）等各种疾病的发展过程中起着关键作用。这篇综述深入探讨了微肽对健康和病理的双重影响，探讨了它们在维持正常生理平衡中的关键作用，并探究了它们在疾病的诱发和发展中的参与。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Briefings in Functional Genomics BIOTECHNOLOGY & APPLIED MICROBIOLOGY-GENETICS & HEREDITY

CiteScore

6.30

自引率

2.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Briefings in Functional Genomics publishes high quality peer reviewed articles that focus on the use, development or exploitation of genomic approaches, and their application to all areas of biological research. As well as exploring thematic areas where these techniques and protocols are being used, articles review the impact that these approaches have had, or are likely to have, on their field. Subjects covered by the Journal include but are not restricted to: the identification and functional characterisation of coding and non-coding features in genomes, microarray technologies, gene expression profiling, next generation sequencing, pharmacogenomics, phenomics, SNP technologies, transgenic systems, mutation screens and genotyping. Articles range in scope and depth from the introductory level to specific details of protocols and analyses, encompassing bacterial, fungal, plant, animal and human data. The editorial board welcome the submission of review articles for publication. Essential criteria for the publication of papers is that they do not contain primary data, and that they are high quality, clearly written review articles which provide a balanced, highly informative and up to date perspective to researchers in the field of functional genomics.