Increased Serum Terminal Complements Complex Levels in Attention Deficit Hyperactivity Disorder Children.

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Iranian Journal of Medical Sciences Pub Date : 2024-04-01 DOI:10.30476/IJMS.2023.97556.2934
Sawsan M Jabbar Al-Hasnawi, Mays Amer Noori, Amer Fadhil Al-Haidari, Munther J Hussain
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Abstract

Background: Attention deficit hyperactivity disorder (ADHD) is a widespread neuropsychiatric disorder in both children and adolescents, which is associated with social isolation and poor academic performance. Complement proteins are regarded as a major player in inflammation and disease development for several neuropsychiatric diseases such as schizophrenia and bipolar diseases. As clarified by previous data, increased levels of complement molecules and other immunological markers as cytokines were demonstrated in these disorders. Limited studies have investigated complement proteins particularly terminal complement complex or membrane attack complex (C5b-9) among ADHD patients. The present research aims to elucidate the association between C5b-9 complex protein and ADHD.

Methods: This is a cross-sectional study. Sera were collected from Al-Hussain Teaching Medical City in Holy Karbala, Iraq, during 2019-2020. Sera were tested for C5-b9 using commercial kits by enzyme-linked immunosorbent assay (ELISA).

Results: In 90 participants included in the study, a significant increment in C5b-9 levels among ADHD patients (P=0.019) was observed. Patients with positive C5b-9 levels had a 2.76 times higher risk of developing ADHD than control subjects. The diagnostic utility for C5b-9 was statistically significant with 71.11% sensitivity, 55.6% specificity, and a high negative predictive value (97.3%).

Conclusion: The study concluded elevation of the C5b-9 terminal complements complex levels in ADHD patients, which could point to the association of complement proteins as inflammatory markers with the ADHD disease process.

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注意缺陷多动障碍儿童血清末端补体复合物水平升高。
背景:注意缺陷多动障碍(ADHD)是一种广泛存在于儿童和青少年中的神经精神疾病,与社会隔离和学习成绩差有关。补体蛋白被认为是多种神经精神疾病(如精神分裂症和躁狂症)的炎症和疾病发展的主要参与者。以往的数据表明,在这些疾病中,补体分子和其他免疫标志物(如细胞因子)的水平都有所提高。对多动症患者的补体蛋白,尤其是末端补体复合物或膜攻击复合物(C5b-9)进行调查的研究非常有限。本研究旨在阐明 C5b-9 复合物蛋白与多动症之间的关系:这是一项横断面研究。血清于 2019-2020 年期间从伊拉克圣卡尔巴拉的胡赛因教学医疗城采集。使用商业试剂盒通过酶联免疫吸附试验(ELISA)对血清中的 C5-b9 进行检测:在参与研究的 90 名参与者中,观察到多动症患者的 C5b-9 水平显著增加(P=0.019)。C5b-9水平呈阳性的患者患多动症的风险是对照组的2.76倍。C5b-9的诊断效用具有统计学意义,敏感性为71.11%,特异性为55.6%,阴性预测值较高(97.3%):研究得出结论,ADHD 患者体内 C5b-9 末端补体复合物水平升高,这可能表明补体蛋白作为炎症标志物与 ADHD 疾病过程有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
0.00%
发文量
84
审稿时长
12 weeks
期刊介绍: The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of com­muni­cation for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science re­search experiences on prevalent diseases in the region and analysis of various regional problems.
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