[Mechanisms of bone formation by primary cilia].

Folia Pharmacologica Japonica Pub Date : 2024-07-01 Epub Date: 2024-04-26 DOI:10.1254/fpj.23113
Masaki Saito, Gen-Ichi Atsumi
{"title":"[Mechanisms of bone formation by primary cilia].","authors":"Masaki Saito, Gen-Ichi Atsumi","doi":"10.1254/fpj.23113","DOIUrl":null,"url":null,"abstract":"<p><p>Primary cilia are immotile cilia assembled from the centriole-derived basal body, and they protrude on the cell surface in almost all cell types during the cell cycle G<sub>0</sub> phase. Due to the diffusion barrier at the ciliary base, cilia harbor selective G protein-coupled receptors, growth factor receptors, and ion channels on their membrane. Thus, cilia act as sensory organelles, regulating the proliferation and differentiation of the cells and promoting the formation and maturation of various organs including bone, brain, and kidney. It has been unveiled that malformation and dysregulation of cilia cause organ dysplasia, so-called ciliopathy, thus research on primary cilia has become active during the past 20 years. Research on the roles of cilia in bone formation and its regulatory mechanisms have also progressed. It is widely recognized that cilia of preosteoblasts receive hedgehog and promote differentiation of the cells to osteoblasts, resulting in the formation of skulls and long bones. Recently, it has been shown that a membrane-associated protein 4.1G is important in ciliogenesis, hedgehog signaling, and osteoblast differentiation in neonatal bone formation. In this review, we would like to summarize the roles of primary cilia in bone formation and their regulatory mechanisms including the contribution of 4.1G.</p>","PeriodicalId":12208,"journal":{"name":"Folia Pharmacologica Japonica","volume":" ","pages":"198-202"},"PeriodicalIF":0.0000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Folia Pharmacologica Japonica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1254/fpj.23113","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/4/26 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Primary cilia are immotile cilia assembled from the centriole-derived basal body, and they protrude on the cell surface in almost all cell types during the cell cycle G0 phase. Due to the diffusion barrier at the ciliary base, cilia harbor selective G protein-coupled receptors, growth factor receptors, and ion channels on their membrane. Thus, cilia act as sensory organelles, regulating the proliferation and differentiation of the cells and promoting the formation and maturation of various organs including bone, brain, and kidney. It has been unveiled that malformation and dysregulation of cilia cause organ dysplasia, so-called ciliopathy, thus research on primary cilia has become active during the past 20 years. Research on the roles of cilia in bone formation and its regulatory mechanisms have also progressed. It is widely recognized that cilia of preosteoblasts receive hedgehog and promote differentiation of the cells to osteoblasts, resulting in the formation of skulls and long bones. Recently, it has been shown that a membrane-associated protein 4.1G is important in ciliogenesis, hedgehog signaling, and osteoblast differentiation in neonatal bone formation. In this review, we would like to summarize the roles of primary cilia in bone formation and their regulatory mechanisms including the contribution of 4.1G.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
[初级纤毛形成骨的机制]。
原发性纤毛是由中心粒衍生的基部体组装而成的不动纤毛,几乎所有类型的细胞都会在细胞周期的 G0 阶段突出于细胞表面。由于纤毛基部存在扩散屏障,纤毛膜上藏有选择性 G 蛋白偶联受体、生长因子受体和离子通道。因此,纤毛作为感觉细胞器,可调节细胞的增殖和分化,促进骨、脑和肾等各种器官的形成和成熟。人们发现,纤毛的畸形和失调会导致器官发育不良,即所谓的纤毛病,因此,近 20 年来,对原生纤毛的研究日趋活跃。关于纤毛在骨骼形成中的作用及其调控机制的研究也取得了进展。人们普遍认为,前成骨细胞的纤毛能接收刺猬蛋白,并促进细胞向成骨细胞分化,从而形成头骨和长骨。最近的研究表明,膜相关蛋白 4.1G 在新生儿骨骼形成过程中的纤毛生成、刺猬信号转导和成骨细胞分化中起着重要作用。在本综述中,我们将总结初级纤毛在骨形成中的作用及其调控机制,包括 4.1G 的贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Folia Pharmacologica Japonica
Folia Pharmacologica Japonica Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
0.40
自引率
0.00%
发文量
132
期刊最新文献
[Deep brain imaging by using GRIN lens].
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1