Alpha and Beta Radiation for Theragnostics

IF 3 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING PET Clinics Pub Date : 2024-04-29 DOI:10.1016/j.cpet.2024.03.006
Hong Song MD, PhD , George Sgouros PhD
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用于温度测量的 α 和 β 辐射。
放射性核素靶向治疗(TRT)从一开始使用碘-131,发展到现在使用带有镥-177 等β发射同位素的载体分子,取得了长足的进步。随着治疗神经内分泌肿瘤的 Lu-177-DOTATATE 和治疗前列腺癌的 Lu-177-PSMA-617 取得成功,人们正在探索将 Cu-67 和 Tb-161 等其他几种β发射放射性同位素用于 TRT。该领域还扩展到α靶向治疗(TAT),如用镭-223治疗前列腺癌骨转移,以及其他几种带有载体分子的α发射放射性同位素,如Ac-225和Pb-212,正在进行临床试验。尽管取得了这些进展,但 TRT 治疗各种实体瘤的范围以及与免疫疗法等其他疗法的整合仍在研究之中。抗体药物结合物的成功进一步补充了 TRT 的治疗,但治疗优化仍面临挑战。
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来源期刊
PET Clinics
PET Clinics RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
5.70
自引率
3.80%
发文量
78
期刊介绍: As the clinical applications of positron emission tomography (PET) increase, the new PET Clinics brings together the combined expertise of leading authorities in the field to provide you incisive clinical reviews on advances in the use of PET and combined PET/CT. Published quarterly, PET Clinics provides concise, practical guidance on the clinical issues you face every day. It examines PET is effectiveness in cancer diagnosis and staging, as well as exploring PET is usefulness in the areas of dementia, myocardial viability, and other conditions. Full-color images featured throughout. Topics covered include Breast Cancer, Alzheimer is Disease and Dementia, Lymphoma, Lung Cancer, Cardiology, Pediatric Applications, Infection and Inflammation.
期刊最新文献
Contents Clinical Applications of PET Imaging in Alzheimer’s Disease CT, MRI, and PET Imaging in Patients with Traumatic Brain Injury Structural and Molecular Imaging of Aging Brain CME Accreditation Page
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