Molecular Imaging with PET-CT and PET-MRI in Pediatric Musculoskeletal Diseases

IF 4.6 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Seminars in nuclear medicine Pub Date : 2024-05-01 DOI:10.1053/j.semnuclmed.2024.03.003
Kip E. Guja MD, PhD , Gerald Behr MD , Akshay Bedmutha MD , Marlena Kuhn BS , Helen R. Nadel MD , Neeta Pandit-Taskar MD
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Abstract

Molecular imaging has emerged as an integral part of oncologic imaging. Given the physiologic changes that precede anatomic changes, molecular imaging can enable early detection of disease and monitoring of response. [18F] Fluorodeoxyglucose (FDG) Positron emission tomography (PET) is the predominant molecular imaging modality used in oncologic assessment and can be performed using PET/CT or PET/MR. In pediatric patients, PET/MRI imaging is generally preferred due to low radiation exposure and PET/MRI is particularly advantageous for imaging musculoskeletal (MSK) diseases, as MRI provides superior characterization of tissue changes as compared to CT. In this article, we provide an overview of the typical role of PET CT/MRI in assessment of some common pediatric malignancies and benign MSK diseases with case examples. We also discuss the relative advantages of PET/MRI compared to PET/CT, and review published data with a primary focus on the use of PET/MR.

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利用 PET-CT 和 PET-MRI 对小儿肌肉骨骼疾病进行分子成像。
分子成像已成为肿瘤成像不可或缺的一部分。鉴于生理变化先于解剖变化,分子成像可实现疾病的早期检测和反应监测。[18F]氟脱氧葡萄糖(FDG)正电子发射断层扫描(PET)是用于肿瘤评估的主要分子成像方式,可通过 PET/CT 或 PET/MR 进行。在儿科患者中,PET/MRI 成像因辐射量低而受到青睐,PET/MRI 在成像肌肉骨骼(MSK)疾病方面尤其具有优势,因为与 CT 相比,MRI 能更好地描述组织变化。在本文中,我们通过病例概述了 PET CT/MRI 在评估一些常见儿科恶性肿瘤和良性 MSK 疾病中的典型作用。我们还讨论了 PET/MRI 与 PET/CT 相比的相对优势,并回顾了已发表的数据,主要侧重于 PET/MR 的使用。
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来源期刊
Seminars in nuclear medicine
Seminars in nuclear medicine 医学-核医学
CiteScore
9.80
自引率
6.10%
发文量
86
审稿时长
14 days
期刊介绍: Seminars in Nuclear Medicine is the leading review journal in nuclear medicine. Each issue brings you expert reviews and commentary on a single topic as selected by the Editors. The journal contains extensive coverage of the field of nuclear medicine, including PET, SPECT, and other molecular imaging studies, and related imaging studies. Full-color illustrations are used throughout to highlight important findings. Seminars is included in PubMed/Medline, Thomson/ISI, and other major scientific indexes.
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