High-grade Serous Carcinoma Occurring in a Serous Cystadenoma on the Background of a Serous Tubal Intraepithelial Carcinoma (STIC)-like Lesion: A Case Report With Literature Review.

IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY International Journal of Gynecological Pathology Pub Date : 2024-11-01 Epub Date: 2024-04-18 DOI:10.1097/PGP.0000000000001018
Filipp Vladimirovich Novikov, Aleksandr Grigorevich Anufriev, Gennadii Dmitrievich Efremov
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Abstract

At present, the prevailing concept is that high-grade serous carcinoma (HGSC) arises from the fallopian tubes (FTs). We report an HGSC case occurring in a serous ovarian cyst against the background of a serous tubal intraepithelial carcinoma (STIC)-like lesion. We also provide a literature review that contains references to clinical cases of the occurrence of STIC-like lesions in the ovary and phylogenetic studies that do not always reveal obvious bonds between early dysplastic serous lesions and HGSC. The article discusses cases of association between HGSCs of serous borderline tumors (SBTs) and low-grade serous carcinomas (LGSCs) in the context of their possible histogenetic relationship. We propose a concept in which high-grade serous carcinogenesis, represented by the p53-signature-STIC-HGSC continuity, occurs in the serous epithelium of both the FT and other locations.

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在浆液性输卵管上皮内瘤(STIC)样病变背景下发生于浆液性囊腺瘤的高级别浆液性癌:病例报告与文献综述。
目前,流行的观点是高级别浆液性癌(HGSC)来源于输卵管。我们报告了一个发生在浆液性卵巢囊肿中的 HGSC 病例,其背景是浆液性输卵管上皮内癌(STIC)样病变。我们还提供了一篇文献综述,其中包括卵巢STIC样病变的临床病例和系统发育研究的参考文献,这些研究并不总能揭示早期浆液性病变发育不良与HGSC之间的明显联系。文章讨论了浆液性边界瘤(SBT)的 HGSC 与低级别浆液性癌(LGSC)之间可能存在的组织遗传学关系。我们提出了一种概念,即高级别浆液性癌发生于 FT 和其他部位的浆液性上皮,以 p53 标志-STIC-HGSC 连续性为代表。
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来源期刊
CiteScore
3.90
自引率
12.50%
发文量
154
审稿时长
6-12 weeks
期刊介绍: International Journal of Gynecological Pathology is the official journal of the International Society of Gynecological Pathologists (ISGyP), and provides complete and timely coverage of advances in the understanding and management of gynecological disease. Emphasis is placed on investigations in the field of anatomic pathology. Articles devoted to experimental or animal pathology clearly relevant to an understanding of human disease are published, as are pathological and clinicopathological studies and individual case reports that offer new insights.
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