Visual Field and Optical Coherence Tomography Parameters With and Without Positive Family History of Glaucoma.

Sabitri Bhatta, Suresh Awasthi, Gyan Bahadur Basnet, Indra Man Maharjan
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Abstract

Background: To evaluate the Retinal Nerve Fiber Layer and Ganglion Cell Complex thickness using Spectral Domain Optical Coherence Tomography with and without positive family history of Primary Open Angle Glaucoma and its relation to visual field.

Methods: Total 120 eyes with each subjects with positive family history of Primary Open Angle Glaucoma (Group I, n=30) and healthy subjects without positive family history of Primary Open Angle Glaucoma (Group II, n=30) undergone complete ophthalmic evaluation with Retinal Nerve Fiber Layer, Ganglion Cell Complex and VF obtained from Spectral Domain Optical Coherence Tomography RTVue-100 and Humphrey visual field respectively .The measurements were analyzed and compared among two groups using independent-t test by using SPSS version 23.The relationship of Retinal Nerve Fiber Layer with visual field were evaluated with correlation analysis.

Results: There were 75 patients included in the study.nasal, temporal RNFL and average Ganglion Cell Complex was significantly lower and thinner in Group I with mean difference of -8.53±2.30 µm (p<0.001), -7.35±3.34 µm (p<0.001), -8.52±3.58µm (p<0.001),-11.87±2.24µm (p<0.001), -5.31±1.95µm (p<0.001) and -8.05±1.52µm (p<0.001) respectively. Correlation plot with Retinal Nerve Fiber Layer thickness as predictor of Mean Deviation and Pattern Standard Deviation indicated statistically significant degree of determination in Group I (r=0.455 and r=0.623, p<0.001 and p<0.001).

Conclusions: The Optical Coherence Tomography and visual field Parameters are lower in group I and used as an early predictor, diagnosis, monitoring and management.

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有无阳性青光眼家族史的视野和光学相干断层扫描参数。
背景:使用光谱域光学相干断层扫描评估有原发性开角型青光眼阳性家族史和无原发性开角型青光眼阳性家族史的受试者的视网膜神经纤维层和神经节细胞复合体厚度及其与视野的关系:有原发性开角型青光眼阳性家族史的受试者(I组,n=30)和无原发性开角型青光眼阳性家族史的健康受试者(II组,n=30)共120只眼睛接受了完整的眼科评估,分别用光域光学相干断层扫描RTVue-100和汉弗莱视野获得视网膜神经纤维层、神经节细胞复合体和视野。使用 SPSS 23 版对测量结果进行分析,并使用独立 t 检验对两组数据进行比较:第一组患者的光学相干断层扫描和视野参数较低,可作为早期预测、诊断、监测和管理的依据。
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来源期刊
CiteScore
1.40
自引率
0.00%
发文量
81
审稿时长
15 weeks
期刊介绍: The journal publishes articles related to researches done in the field of biomedical sciences related to all the discipline of the medical sciences, medical education, public health, health care management, including ethical and social issues pertaining to health. The journal gives preference to clinically oriented studies over experimental and animal studies. The Journal would publish peer-reviewed original research papers, case reports, systematic reviews and meta-analysis. Editorial, Guest Editorial, Viewpoint and letter to the editor are solicited by the editorial board. Frequently Asked Questions (FAQ) regarding manuscript submission and processing at JNHRC.
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