The relation of body adiposity to the outcomes of thoracoscopic lobectomy for lung cancer - a single-center cohort study.

IF 0.6 Q4 SURGERY Kardiochirurgia I Torakochirurgia Polska Pub Date : 2024-03-01 Epub Date: 2024-03-30 DOI:10.5114/kitp.2024.138524
Piotr Gabryel, Piotr Skrzypczak, Lidia Szlanga, Aleksandra Kaluzniak-Szymanowska, Magdalena Sielewicz, Alessio Campisi, Magdalena Roszak, Cezary Piwkowski
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Abstract

Introduction: The outcomes of lung cancer surgery depend on the patients' nutritional status. Body fat percentage (BF%) is one of the indicators of body composition and nutritional status. Direct measurement of BF% is complicated, requires significant resources and is rarely performed. The CUN-BAE (Clínica Universidad de Navarra - Body Adiposity Estimator) index has been shown to accurately predict BF% is several clinical settings, but its relation to the outcomes of lung surgery has not been reported so far.

Aim: To determine the relation of the BF% to the outcomes of thoracoscopic lobectomy.

Material and methods: This retrospective study included 1,183 patients who underwent thoracoscopic lobectomy for non-small cell lung cancer between June 1999, and September 2019 at one department. BF% was calculated according to the Clínica Universidad de Navarra - Body Adiposity Estimator equation. The primary endpoints were postoperative complications and long-term survival.

Results: Univariate analysis showed that higher BF% was related to lower incidence of complications (p = 0.001), including prolonged air leak (p < 0.001), atelectasis (p < 0.05), psychosis (p < 0.001), reoperations (p < 0.05), and shorter chest drainage (p = 0.001) and hospitalization duration (p < 0.001). Multivariate analysis showed that higher BF% was correlated with lower risk of complications (p = 0.005; OR = 0.964; 95% CI: 0.940 to 0.989), including prolonged air leak (p < 0.001; OR = 0.923; 95% CI: 0.886 to 0.962), and shorter duration of chest drainage (p < 0.001; B = -0.046; 95% CI: -0.069 to -0.023) and hospitalization (p < 0.001; B = -0.112; 95% CI: -0.176 to -0.048). Cox proportional hazards regression analysis showed that BF% was not related to long-term survival.

Conclusions: Body fat percentage is a valuable tool that can help predict the short-term outcomes of minimally lobectomy for lung cancer.

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身体脂肪与胸腔镜肺叶切除术治疗肺癌效果的关系--一项单中心队列研究。
导言肺癌手术的效果取决于患者的营养状况。体脂率(BF%)是身体成分和营养状况的指标之一。直接测量体脂率比较复杂,需要大量资源,而且很少进行。CUN-BAE(Clínica Universidad de Navarra - Body Adiposity Estimator,纳瓦拉大学身体脂肪估计器)指数已被证明可在多种临床环境中准确预测体脂率,但其与肺部手术结果的关系迄今尚未见报道:这项回顾性研究纳入了1999年6月至2019年9月期间在一个科室接受胸腔镜肺叶切除术治疗非小细胞肺癌的1183名患者。BF%是根据纳瓦拉大学诊所--身体脂肪估计方程计算得出的。主要终点是术后并发症和长期生存:单变量分析显示,BF%越高,并发症发生率越低(p = 0.001),包括漏气时间延长(p < 0.001)、肺不张(p < 0.05)、精神病(p < 0.001)、再次手术(p < 0.05)、胸腔引流时间缩短(p = 0.001)和住院时间缩短(p < 0.001)。多变量分析显示,较高的 BF% 与较低的并发症风险相关(p = 0.005;OR = 0.964;95% CI:0.940 至 0.989),包括长时间漏气(p < 0.001;OR = 0.923; 95% CI: 0.886 to 0.962),以及较短的胸腔引流时间(P < 0.001; B = -0.046; 95% CI: -0.069 to -0.023)和住院时间(P < 0.001; B = -0.112; 95% CI: -0.176 to -0.048)。Cox比例危险回归分析表明,体脂率与长期生存无关:结论:体脂率是一种有价值的工具,有助于预测肺癌微创肺叶切除术的短期疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
0.90
自引率
14.30%
发文量
44
审稿时长
6-12 weeks
期刊介绍: Polish Journal of Thoracic and Cardiovascular Surgery is a quarterly aimed at cardiologists, cardiosurgeons and thoracic surgeons. Includes the original works (experimental, research and development), illustrative and casuistical works about cardiology and cardiosurgery.
期刊最新文献
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