Effects of APOE4 on omega-3 brain metabolism across the lifespan.

IF 11.4 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Trends in Endocrinology and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-04-12 DOI:10.1016/j.tem.2024.03.003
Brandon Ebright, Marlon V Duro, Kai Chen, Stan Louie, Hussein N Yassine
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Abstract

Omega-3 (n-3) polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA), have important roles in human nutrition and brain health by promoting neuronal functions, maintaining inflammatory homeostasis, and providing structural integrity. As Alzheimer's disease (AD) pathology progresses, DHA metabolism in the brain becomes dysregulated, the timing and extent of which may be influenced by the apolipoprotein E ε4 (APOE4) allele. Here, we discuss how maintaining adequate DHA intake early in life may slow the progression to AD dementia in cognitively normal individuals with APOE4, how recent advances in DHA brain imaging could offer insights leading to more personalized preventive strategies, and how alternative strategies targeting PUFA metabolism pathways may be more effective in mitigating disease progression in patients with existing AD dementia.

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APOE4对整个生命周期中omega-3脑代谢的影响。
欧米伽-3(n-3)多不饱和脂肪酸(PUFA),如二十二碳六烯酸(DHA),通过促进神经元功能、维持炎症平衡和提供结构完整性,在人类营养和大脑健康中发挥着重要作用。随着阿尔茨海默病(AD)病理的发展,大脑中的 DHA 代谢会出现失调,其发生的时间和程度可能会受到载脂蛋白 E ε4(APOE4)等位基因的影响。在此,我们将讨论在生命早期保持足够的 DHA 摄入量可如何减缓认知正常的 APOE4 患者向 AD 痴呆症的进展,DHA 脑成像的最新进展可如何为制定更个性化的预防策略提供启示,以及针对 PUFA 代谢途径的替代策略可如何更有效地缓解现有 AD 痴呆症患者的疾病进展。
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来源期刊
Trends in Endocrinology and Metabolism
Trends in Endocrinology and Metabolism 医学-内分泌学与代谢
CiteScore
20.10
自引率
0.00%
发文量
98
审稿时长
82 days
期刊介绍: Trends in Endocrinology and Metabolism (TEM) stands as a premier Reviews journal in the realms of metabolism and endocrinology. Our commitment is reflected in the publication of refined, concise, and highly impactful articles that delve into cutting-edge topics, encompassing basic, translational, and clinical aspects. From state-of-the-art treatments for endocrine diseases to groundbreaking developments in molecular biology, TEM provides comprehensive coverage. Explore recent advancements in diabetes, endocrine diseases, obesity, neuroendocrinology, immunometabolism, molecular and cellular biology, and a myriad of other areas through our journal. TEM serves as an invaluable resource for researchers, clinicians, lecturers, teachers, and students. Each monthly issue is anchored by Reviews and Opinion articles, with Reviews meticulously chronicling recent and significant developments, often contributed by leading researchers in specific fields. Opinion articles foster debate and hypotheses. Our shorter pieces include Science & Society, shedding light on issues at the intersection of science, society, and policy; Spotlights, which focus on exciting recent developments in the literature, and single-point hypotheses as Forum articles. We wholeheartedly welcome and encourage responses to previously published TEM content in the form of Letters.
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