Potential therapeutic targets of fibrosis in inflammatory rheumatic diseases

IF 4.5 2区 医学 Q1 RHEUMATOLOGY Best Practice & Research in Clinical Rheumatology Pub Date : 2024-05-01 DOI:10.1016/j.berh.2024.101945
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Abstract

Fibrosis is commonly associated with chronic rheumatic diseases, and causes substantial morbidity and mortality. Treatment of fibrosis is extremely challenging but is badly needed, as approved antifibrotic therapies fibrosis do not halt its progression, which will be discussed with a focus on pulmonary fibrosis. Findings from recent studies indicate several therapeutic targets for treating fibrosis. Interleukin-11 is emerging as a fibrogenic cytokine whose activity can be blocked with neutralizing monoclonal antibodies. Fibroblast activation protein (FAP) is highly expressed by activated fibroblasts in inflammatory and fibrotic tissues. Targeting FAP with different modalities has been extensively explored as adjunct treatment for cancer, which can also apply to treating fibrosis in rheumatic diseases.

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炎症性风湿病纤维化的潜在治疗目标。
纤维化通常与慢性风湿病有关,会导致大量的发病率和死亡率。纤维化的治疗极具挑战性,但亟需治疗,因为已获批准的纤维化抗纤维化疗法并不能阻止纤维化的发展,本文将重点讨论肺纤维化。最近的研究结果表明了治疗肺纤维化的几个治疗靶点。白细胞介素-11正在成为一种纤维化细胞因子,可通过中和单克隆抗体阻断其活性。成纤维细胞活化蛋白(FAP)在炎症和纤维化组织中由活化的成纤维细胞高表达。以 FAP 为靶点的不同模式已被广泛用于癌症的辅助治疗,这也适用于治疗风湿性疾病中的纤维化。
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来源期刊
CiteScore
9.40
自引率
0.00%
发文量
43
审稿时长
27 days
期刊介绍: Evidence-based updates of best clinical practice across the spectrum of musculoskeletal conditions. Best Practice & Research: Clinical Rheumatology keeps the clinician or trainee informed of the latest developments and current recommended practice in the rapidly advancing fields of musculoskeletal conditions and science. The series provides a continuous update of current clinical practice. It is a topical serial publication that covers the spectrum of musculoskeletal conditions in a 4-year cycle. Each topic-based issue contains around 200 pages of practical, evidence-based review articles, which integrate the results from the latest original research with current clinical practice and thinking to provide a continuous update. Each issue follows a problem-orientated approach that focuses on the key questions to be addressed, clearly defining what is known and not known. The review articles seek to address the clinical issues of diagnosis, treatment and patient management. Management is described in practical terms so that it can be applied to the individual patient. The serial is aimed at the physician in both practice and training.
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