The role of THBS1 and PDGFD in the immune microenvironment of Helicobacter pylori-associated gastric cancer

IF 1.1 4区 医学 Q4 GASTROENTEROLOGY & HEPATOLOGY Arab Journal of Gastroenterology Pub Date : 2024-05-01 DOI:10.1016/j.ajg.2024.02.001
Yun Zhou , Shixiong Liu , Ya Zheng , Yuping Wang , Yongning Zhou
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Abstract

Background and study aims

Immunotherapy has emerged as a hot topic in cancer treatment in recent years and has also shown potential in the treatment of Helicobacter pylori-associated gastric cancer. However, there is still a need to identify potential immunotherapy targets.

Material and methods

We used the GSE116312 dataset of Helicobacter pylori-associated gastric cancer to identify differentially expressed genes, which were then overlapped with immune genes from the ImmPort database. The identified immune genes were used to classify gastric cancer samples and evaluate the relationship between classification and tumor mutations, as well as immune infiltration. An immune gene-based prognostic model was constructed, and the expression levels of the genes involved in constructing the model were explored in the tumor immune microenvironment.

Results

We successfully identified 60 immune genes and classified gastric cancer samples into two subtypes, which showed differences in prognosis, tumor mutations, immune checkpoint expression, and immune cell infiltration. Subsequently, we constructed an immune prognostic model consisting of THBS1 and PDGFD, which showed significant associations with macrophages and fibroblasts.

Conclusion

We identified abnormal expression of THBS1 and PDGFD in cancer-associated fibroblasts (CAFs) within the tumor immune microenvironment, suggesting their potential as therapeutic targets.

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THBS1和PDGFD在幽门螺杆菌相关性胃癌免疫微环境中的作用
背景和研究目的:近年来,免疫疗法已成为癌症治疗领域的热门话题,在幽门螺杆菌相关性胃癌的治疗中也显示出了潜力。然而,目前仍需确定潜在的免疫治疗靶点:我们使用幽门螺杆菌相关性胃癌的 GSE116312 数据集来识别差异表达基因,然后将其与 ImmPort 数据库中的免疫基因进行重叠。鉴定出的免疫基因被用来对胃癌样本进行分类,并评估分类与肿瘤突变以及免疫浸润之间的关系。我们构建了基于免疫基因的预后模型,并探讨了肿瘤免疫微环境中参与构建模型的基因的表达水平:结果:我们成功鉴定了60个免疫基因,并将胃癌样本分为两个亚型,这两个亚型在预后、肿瘤突变、免疫检查点表达和免疫细胞浸润方面存在差异。随后,我们构建了一个由THBS1和PDGFD组成的免疫预后模型,该模型与巨噬细胞和成纤维细胞有显著关联:结论:我们在肿瘤免疫微环境中的癌症相关成纤维细胞(CAFs)中发现了THBS1和PDGFD的异常表达,这表明它们有可能成为治疗靶点。
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来源期刊
Arab Journal of Gastroenterology
Arab Journal of Gastroenterology Medicine-Gastroenterology
CiteScore
2.70
自引率
0.00%
发文量
52
期刊介绍: Arab Journal of Gastroenterology (AJG) publishes different studies related to the digestive system. It aims to be the foremost scientific peer reviewed journal encompassing diverse studies related to the digestive system and its disorders, and serving the Pan-Arab and wider community working on gastrointestinal disorders.
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