Impact of Various Concentrations of Low-Dose Atropine on Pupillary Diameter and Accommodative Amplitude in Children with Myopia.

IF 1.9 4区 医学 Q2 OPHTHALMOLOGY Journal of Ocular Pharmacology and Therapeutics Pub Date : 2024-05-01 Epub Date: 2024-04-15 DOI:10.1089/jop.2023.0173
Huy D M Tran, Thao T X Ha, Yen H Tran, Minas Coroneo, Tuan D Tran, Trang U Truong, Padmaja Sankaridurg
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Abstract

Purpose: To assess over 2 weeks, the effect of 3 different low concentrations of atropine on pupillary diameter and accommodative amplitude in children with myopia. Methods: Fifty-eight children with myopia [spherical equivalent (SE) of -0.50 diopters (D) or worse, astigmatism of less than or equal to 2.00 D] were randomly allocated to 3 groups receiving 0.01%, 0.02%, or 0.03% atropine eye drops, once nightly for 2 weeks. The primary outcome was the change from baseline in pupillary diameter and accommodative amplitude with each of the concentrations. Results: Fifty-seven participants (114 eyes), aged between 6 and 12 years, completed the 2-week trial (mean age 9.3 ± 1.7 years and mean SE -3.53 ± 1.79 D). After 2 weeks of use, all the 3 concentrations were found to have a statistically significant effect on both the pupillary diameter and accommodative amplitude. Accommodative amplitude reduced by an average of 5.23 D, 9.28 D, and 9.32 D, and photopic pupil size increased by an average of 0.95 ± 1.05 mm, 1.65 ± 0.93 mm, and 2.16 ± 0.88 mm with 0.01%, 0.02%, and 0.03%, respectively. Of the eyes, a total of 5.3% and 5.9% of the eyes on 0.02% and 0.03% atropine had a mean residual accommodative amplitude of <5 D. The percentage of eyes having a pupillary dilation >3 mm were 4.8%, 10.5%, and 23.5% for 0.01%, 0.02%, and 0.03% atropine, respectively. Conclusions: Low-dose atropine had an effect on pupillary diameter and accommodative amplitude. With the highest concentration assessed, that is, 0.03% nearly 1 of 4 eyes had pupillary dilation of >3 mm. Clinical Trial Registration number: NCT03699423.

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不同浓度的低剂量阿托品对近视儿童瞳孔直径和屈光度的影响
目的:在两周内评估 3 种不同低浓度阿托品对近视儿童瞳孔直径和容纳幅度的影响。方法:对 58 名近视儿童(球面等效度数为 1.0 或 1.0 以上)进行测试:将 58 名近视儿童[球面等效度数(SE)为-0.50 屈光度(D)或更差,散光小于或等于 2.00 屈光度]随机分配到 3 组,分别滴用 0.01%、0.02% 或 0.03% 的阿托品眼药水,每晚一次,持续 2 周。主要结果是每种浓度的瞳孔直径和屈光幅度与基线相比的变化。研究结果57名参与者(114只眼睛)完成了为期2周的试验,他们的年龄在6至12岁之间(平均年龄为9.3 ± 1.7岁,平均SE为-3.53 ± 1.79 D)。使用 2 周后,发现所有 3 种浓度的药物对瞳孔直径和屈光幅度都有显著的统计学影响。使用 0.01%、0.02% 和 0.03% 时,屈光幅度分别平均减小 5.23 D、9.28 D 和 9.32 D,光瞳直径分别平均增大 0.95 ± 1.05 mm、1.65 ± 0.93 mm 和 2.16 ± 0.88 mm。在使用 0.02% 和 0.03% 阿托品的眼睛中,分别有 5.3% 和 5.9% 的眼睛的平均残余容纳振幅为 3 毫米,而使用 0.01%、0.02% 和 0.03% 阿托品的眼睛的平均残余容纳振幅分别为 4.8%、10.5% 和 23.5%。结论小剂量阿托品对瞳孔直径和容纳振幅有影响。在评估的最高浓度(即 0.03%)下,4 只眼睛中有近 1 只的瞳孔扩张大于 3 毫米。临床试验注册号:NCT03699423:NCT03699423。
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来源期刊
CiteScore
4.60
自引率
4.30%
发文量
72
审稿时长
1 months
期刊介绍: Journal of Ocular Pharmacology and Therapeutics is the only peer-reviewed journal that combines the fields of ophthalmology and pharmacology to enable optimal treatment and prevention of ocular diseases and disorders. The Journal delivers the latest discoveries in the pharmacokinetics and pharmacodynamics of therapeutics for the treatment of ophthalmic disorders. Journal of Ocular Pharmacology and Therapeutics coverage includes: Glaucoma Cataracts Retinal degeneration Ocular infection, trauma, and toxicology Ocular drug delivery and biotransformation Ocular pharmacotherapy/clinical trials Ocular inflammatory and immune disorders Gene and cell-based therapies Ocular metabolic disorders Ocular ischemia and blood flow Proliferative disorders of the eye Eyes on Drug Discovery - written by Gary D. Novack, PhD, featuring the latest updates on drug and device pipeline developments as well as policy/regulatory changes by the FDA.
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