Association Between Neuroinflammation and Parkinson's Disease: A Comprehensive Mendelian Randomization Study.

IF 4.6 2区医学 Q1 NEUROSCIENCES Molecular Neurobiology Pub Date : 2024-12-01 Epub Date: 2024-05-06 DOI:10.1007/s12035-024-04197-2

YiNi Wang, XinYu Shi, YaPing Yin, Fei Yang, YiNan Zhang, Xin He, Da Wen, Bai-Xiang Li, Kun Ma

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Abstract

The objective of the study is to determine the causal relationship and potential mechanisms between Parkinson's disease (PD) and neuroinflammatory and neurotoxic mediators. We conducted two-sample Mendelian randomization (2SMR) study and multivariable Mendelian randomization (MVMR) analysis to investigate the causality between PD and neuroinflammatory and neurotoxic mediators. The mediation analysis with MR was also conducted to determine the potential mediating effect of neuroinflammatory and neurotoxic mediators between asthma and PD. Genetically predicted levels of nine neuroinflammation were associated with changes in PD risk. The associations of PD with CCL24, galectin-3 levels, haptoglobin, and Holo-Transcobalamin-2 remained significant in multivariable analyses. The mediation analysis with MR revealed that asthma affects PD through CCL24 and galectin-3. The results showed neuroinflammation could affect the pathogenesis of PD. In the combined analysis of these nine variables, CCL24, galectin-3 levels, HP, and Holo-Transcobalamin-2 alone were found to be significant. Asthma plays an intermediary role through CCL24 and galectin-3 levels.

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神经炎症与帕金森病之间的关系：孟德尔随机综合研究

本研究旨在确定帕金森病（PD）与神经炎症和神经毒性介质之间的因果关系和潜在机制。我们进行了双样本孟德尔随机化（2SMR）研究和多变量孟德尔随机化（MVMR）分析，以研究帕金森病与神经炎症和神经毒性介质之间的因果关系。此外，还进行了MR中介分析，以确定神经炎症和神经毒性介质在哮喘与痹症之间的潜在中介效应。基因预测的九种神经炎症水平与肢端麻痹症风险的变化相关。在多变量分析中，肢端麻痹症与CCL24、galectin-3水平、血红蛋白和Holo-Transcobalamin-2的关系仍然显著。利用MR进行的中介分析表明，哮喘通过CCL24和galectin-3影响肢端麻痹症。结果表明，神经炎症可能会影响帕金森病的发病机制。在对这九个变量的综合分析中，发现CCL24、galectin-3水平、HP和Holo-Transcobalamin-2单独具有显著性。哮喘通过CCL24和galectin-3水平发挥中介作用。

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来源期刊

Molecular Neurobiology 医学-神经科学

CiteScore

9.00

自引率

2.00%

发文量

480

审稿时长

1 months

期刊介绍： Molecular Neurobiology is an exciting journal for neuroscientists needing to stay in close touch with progress at the forefront of molecular brain research today. It is an especially important periodical for graduate students and "postdocs," specifically designed to synthesize and critically assess research trends for all neuroscientists hoping to stay active at the cutting edge of this dramatically developing area. This journal has proven to be crucial in departmental libraries, serving as essential reading for every committed neuroscientist who is striving to keep abreast of all rapid developments in a forefront field. Most recent significant advances in experimental and clinical neuroscience have been occurring at the molecular level. Until now, there has been no journal devoted to looking closely at this fragmented literature in a critical, coherent fashion. Each submission is thoroughly analyzed by scientists and clinicians internationally renowned for their special competence in the areas treated.